0 Systems Biology Glossary ● Systems biology:understanding of the function of a biological system-tissue,organ,or organism-as a whole Genomics-study of gene expression,protein and metabolite profiles Epigenomics-DNA methylation(cells turn genes on/off) Transcriptomics-mRNA profile(functional genomics;microarrays) Proteomics-cell proteins(proteome) Metabolomics-cellular metabolites(products of gene expression) Metabonomics-organismal metabolites;metabolic profiling Pharmacogenomics-drug effects at the gene expression level Toxicogenomics-toxicity at the gene expression level Bioinformatics-genomic data acquisition,analysis,interpretation OSU rgo
Systems Biology Glossary • Systems biology: understanding of the function of a biological system–tissue, organ, or organism–as a whole. Genomics – study of gene expression, protein and metabolite profiles Epigenomics – DNA methylation (cells turn genes on/off) Transcriptomics – mRNA profile (functional genomics; microarrays) Proteomics – cell proteins (proteome) Metabolomics – cellular metabolites (products of gene expression) Metabonomics – organismal metabolites; metabolic profiling Pharmacogenomics – drug effects at the gene expression level Toxicogenomics – toxicity at the gene expression level Bioinformatics – genomic data acquisition, analysis, interpretation
Sensitive populations:Bimodal Frequency Distribution 0.5 0.45 0.4 0.35 0.3 0.25 0.2 0.15 0.1 Most? More Least Sensitive Sensitive Sensitive 0.05 OSU 0regonstae
Sensitive populations: Bimodal Frequency Distribution 0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45 0.5 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Most? Sensitive More Sensitive Least Sensitive
92 Expressions of Toxicity Modify existing body functions Change speed of cellular reactions ·Reversible injury ·Irreversible injury ·Death Future-gene expression and genotoxicity OSU reo
Expressions of Toxicity • Modify existing body functions • Change speed of cellular reactions • Reversible injury • Irreversible injury • Death Future – gene expression and genotoxicity
All substances are poisons; there is none that is not a poison. The right DOSE differentiates a poison from a remedy (the dose makes the poison) Areolus Phillipus Theophrastus Bombastus von Hohenheim Paracelsus (1493-1541) OS PARESELST 0regonstae 5 oso D©oR
All substances are poisons; there is none that is not a poison. The right DOSE differentiates a poison from a remedy (the dose makes the poison) Areolus Phillipus Theophrastus Bombastus von Hohenheim Paracelsus (1493-1541)
92 29 0 09 TREGORY Honey,let's lay off the Botox for awhile,shall we?" OSU New Yorker magazine 6-11-01 regon
New Yorker magazine 6-11-01