Pesticide Toxicology Jason R Richardson PhD Department of Environmental and Occupational Medicine Robert Wood Johnson Medical School jricha3@eohsi.rutgers.edu
Pesticide Toxicology Jason R Richardson PhD Department of Environmental and Occupational Medicine Robert Wood Johnson Medical School jricha3@eohsi.rutgers.edu
Prehistoric:Sulfur,whale oil,arsenic,nicotine, chrysanthemum,copper Early 19th Century:ethylene bromide,ethylene oxide,carbon disulfide (as fumigants) DDT:Synthesized by Zeideler,1874;Patented Muller,1944(to Geigy) Beginning of World War Il:DDT,dinitrocresol, 2,4-D TEPP:Used as war gas in WW,insecticide in early 1940s,Parathion:Germany 1944
Prehistoric: Sulfur, whale oil, arsenic, nicotine, chrysanthemum, copper Early 19th Century: ethylene bromide, ethylene oxide, carbon disulfide (as fumigants) DDT: Synthesized by Zeideler, 1874; Patented Müller, 1944 (to Geigy) Beginning of World War II: DDT, , dinitrocresol, 2,4-D TEPP: Used as war gas in WW, insecticide in early 1940s, Parathion: Germany 1944
Historic Use of Pesticides slesrwoq5 Jo oqwnu SAIelnwn 110 100 80 60 40 20 10 1800 1850 1900 1950 2000
Cumulative number of chemicals 1800 1850 1900 1950 2000 110 100 80 60 40 20 10 Historic Use of Pesticides
US Pesticide Use Soasonnl 。4.5 billion pounds chemicals per year -890 active ingredients, 30,000 formulations Uses ·75%agricultural ·25%home,garden, structural
US Pesticide Use • 4.5 billion pounds chemicals per year – 890 active ingredients, 30,000 formulations – Uses • 75% agricultural • 25% home, garden, structural
Pesticide Exposure: Environmental-Occupational Interface 。Drift Off-target physical movement of pesticide through air ·Take-home -Contaminated clothing -Pesticide containers brought home
Pesticide Exposure: Environmental-Occupational Interface • Drift – Off-target physical movement of pesticide through air • Take-home – Contaminated clothing – Pesticide containers brought home