3. PathogenesisCell immunityType IV hypersensitivity
3. Pathogenesis Cell immunity Type Ⅳ hypersensitivity
M rubercuosisBacillaryClassnantigenicMHCpoptideCD4 T COT-cellreceptorCYTOKINESDelayed hyporsensitivitylmmunitySensitizedGranulomacellActivatedmacrophagoEpihelioidcellt PhagocytosisCaseoustnecrosisBactericidalactivity
Three consideration are involved inthepathogenesis of TB(l)Quantityofbacteria(2)Virulenceofpathogen(3)Responsiveness ofthebodysensitivity and immune response
Three consideration are involved in the pathogenesis of TB (1) Quantity of bacteria (2) Virulence of pathogen (3) Responsiveness of the body sensitivity and immune response
三. Basic pathologicalchanges of TBreactivitydifferencequantitylesionsvirulencefeatures of tissue
三. Basic pathological changes of TB reactivity quantity virulence features of tissue difference lesions
.ExudationConditionsearly stageimmunityIquantity↑ virulence↑severe hypersensitivity(2) Pathologic changesserous or serofibrinousearly :neutrophilslate :macrophages
1. Exudation (1) Conditions early stage immunity↓quantity↑ virulence↑ severe hypersensitivity (2) Pathologic changes serous or serofibrinous early :neutrophils late :macrophages