s1Glomerulonephritis(GN)Primaryglomerulonephritis:Immune mechanismsSecondary gglomerulonephritis:SLE , HypertensionDiabetes and so on
§1 Glomerulonephritis (GN) ▪ Primary glomerulonephritis: Immune mechanisms ▪ Secondary glomerulonephritis: SLE , Hypertension , Diabetes and so on
一.Etiology and PathogenesisImmunemechanismsGNPrimary
一 . Etiology and Pathogenesis Immune mechanisms Primary GN
() Antigen-Antibody reactionmaincauseAb-Ag complexhypersensitivity
(一) Antigen-Antibody reaction main cause Ab-Ag complex hypersensitivity
l. Antigen(1)EndogenousAg1Glomerular AgGBMAgFoot process AgMembrane of EC②Non-glomerular Ag DNAImmunoglobulinTumor Ag
1. Antigen （1）Endogenous Ag ① Glomerular Ag GBM Ag Foot process Ag Membrane of EC ②Non-glomerular Ag DNA Immunoglobulin Tumor Ag
(2)Exogenous Agbacterium,virusparasite , fungusdrugs , foreignserum
（2）Exogenous Ag bacterium , virus parasite , fungus drugs , foreign serum