3. Renal capsule4.Glomerular barrier functionhighpermeability tor watersmall solutesstructureof filteringrelated tomembranecharge
3. Renal capsule 4. Glomerular barrier function high permeability to water small solutes related to structure charge of filtering membrane
(1)Size - dependentbarrier functiondiscriminates protein moleculesdepending on their size
(1) Size - dependent barrier function discriminates protein molecules depending on their size
(2)Charge-dependentbarrier functionimportant→because albuminisananionic moleculesendothelialcellsialoglycoproteinepithelial cellnegativechargebasalmembraneheparinsulfate
(2) Charge - dependent barrier function ① important→ because albumin is an anionic molecules ② endothelial cell epithelial cell basal membrane→heparin sulfate sialoglycoprotein negative charge
Structure of G B MBs印L?Ca
Structure of G B M
Albumin Normal:can not through the filtrationmembrane- Changes of structure andfunctionproteinuria
③ Albumin ▪ Normal: can not through the filtration membrane ▪ Changes of structure and function proteinuria