CARCINOMA OF THE ENDOMETRIUM Wen Di M.D., Ph D
2003-10-27 Carcinoma of the Endometrium 1 CARCINOMA OF THE ENDOMETRIUM Wen Di , M.D.，Ph.D
One of the commonest gynecological cancers, especially in white Americans it occurs most often in postmenopausal women (up to 80%of cases) with less than 5% diagnosed under 40 years of age 2003-10-27 Carcinoma of the endometrium
2003-10-27 Carcinoma of the Endometrium 2 • One of the commonest gynecological cancers，especially in white Americans， • it occurs most often in postmenopausal women（up to 80％of cases）with less than 5％ diagnosed under 40 years of age．
There is no effective screening programme, but occasionally cervical smears contain endometrial cancer cells or double thickness endometrial ultrasonic thickness of 4mm or more indicates a need for endometrial sampling 2003-10-27 Carcinoma of the endometrium 3
2003-10-27 Carcinoma of the Endometrium 3 There is no effective screening programme，but occasionally cervical smears contain endometrial cancer cells or double thickness endometrial ultrasonic thickness of 4mm or more indicates a need for endometrial sampling．
Risk Factors The actual cause of this cancer is unknown Estrogen given estrogen alone as postmenopausal hormone replacement therapy Estrogen secreting tumors of the ovary are associated with an increased ncidence of endometrial carcinoma 2003-10-27 Carcinoma of the endometrium
2003-10-27 Carcinoma of the Endometrium 4 Risk Factors The actual cause of this cancer is unknown． Estrogen given estrogen alone as postmenopausal hormone replacement therapy Estrogen secreting tumors of the ovary are associated with an increased incidence of endometrial carcinoma．
There can be no doubt that oestrogen can alter the behaviour of this tumour but there is still a question about oestrogen as a primary causal agent Approximately 75%of cases of endometrial cancer occur in the postmenopausal period when estrogen values are low and progesterone is absent. Nulliparity and Pco syndrome(with defective progesterone synthesis ) carry an increased risk 2003-10-27 Carcinoma of the endometrium 5
2003-10-27 Carcinoma of the Endometrium 5 There can be no doubt that oestrogen can alter the behaviour of this tumour but there is still a question about oestrogen as a primary causal agent． Approximately 75％of cases of endometrial cancer occur in the postmenopausal period when estrogen values are low and progesterone is absent．Nulliparity and PCO syndrome（with defective progesterone synthesis）carry an increased risk．