dNa VS Protein Sequence analysis Protein Sequence Analysis DNA Sequence Analysis emphasis on chemistry emphasis on regulation protein structure RNA Structure selection is everywhere signal vs noise(statistics) multiple alignment motif finding comparative proteomics comparative genomIcs data:O(10 8)aa data O(10410)nt Read your probability/statistics primer
DNA vs Protein Sequence Analysis Protein Sequence Analysis DNA Sequence Analysis - emphasis on chemistry - emphasis on regulation - protein structure - RNA structure - selection is everywhere - signal vs noise (statistics) - multiple alignment - motif finding - comparative proteomics - comparative genomics - data: O(10^8) aa - data: O(10^10) nt Read your probability/statistics primer!
Genome Sequencing DNA Sequence Analysis The Language of genomics Shotgun Sequencing Progress: genomes, transcriptomes, etc DNA Sequence Alignment I How to choose a mismatch penalty Comparative Genomics EXamples PipMaker, Phylogenetic Shadowing
Genome Sequencing & DNA Sequence Analysis • The Language of Genomics • Shotgun Sequencing • DNA Sequence Alignment I • Comparative Genomics Examples - Progress: genomes, transcriptomes, etc. - How to choose a mismatch penalty - PipMaker, Phylogenetic Shadowing
Recent media attention The Human Genome (and cloning) The rest of Biology
Recent Media Attention
Genomespeak Bork, Peer, and Richard Copley. "Genome Speak Nature 409(15 February 2001 ): 815 Learn to speak genomic
Genomespeak Bork, Peer, and Richard Copley. " Genome Speak." Nature 409 (15 February 2001): 815. Learn to speak genomic