7.91- Lecture #6 Michael Yaffe Protein Secondary Structure Prediction
7.91 – Lecture #6 Protein Secondary Structure Prediction Michael Yaffe
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7.93 – Lecture #9 Protein Secondary Structure Prediciton -andMotif Searching with Scansite
Outline Brief review of protein structure Chou-Fasman predictions Garnier, Osguthorpe and robson Helical wheels and hydrophobic moments Neural networks Nearest neig hbor methods Consensus prediction approaches
Outline • Brief review of protein structure • Chou-Fasman predictions • Garnier, Osguthorpe and Robson • Helical wheels and hydrophobic moments • Neural networks • Nearest neighbor methods • Consensus prediction approaches
Hierarchy of protein structure Hierarchy of Protein Structure Primary Second F-I-P-A L-F-A-H K-E-L-A T-S-V TSKY Tertiary uaternary
Hierarchy of protein structure
Reasonance of peptide bond implies planarity Peptide bond C N H H R
implies planarity Reasonance of peptide bond