The Immune System (VIn) Pattern Recognition T-cell TCR MHC-ll Protein Pathogen APC Peptide H C MHCIpeptide con BIC 2005-Introduction to artificial Immune Systems- Dr Leandro Nunes de Castro
BIC 2005 - Introduction to Artificial Immune Systems - Dr. Leandro Nunes de Castro 11 ◼ Pattern Recognition: T-cell The Immune System (VII) T-cell TCR
The Immune System (VIIl Basic Immune recognition and activation Mechanisms MHC protein Pathogen Activated b cell Peptide (Plasma ce) Tcel B cell Ⅳ) Activated t cell a Lymphokines after nossal.1993(Ⅵ) BIC 2005-Introduction to artificial Immune Systems- Dr Leandro Nunes de Castro
BIC 2005 - Introduction to Artificial Immune Systems - Dr. Leandro Nunes de Castro 12 The Immune System (VIII) after Nosssal, 1993 ◼ Basic Immune Recognition and Activation Mechanisms
The Immune System (IX Antibody synthesis V V library D library rary Gene rearrangement V卫 Rearranged DNA after Oprea forrest, 1998 13 BIC 2005-Introduction to artificial Immune Systems- Dr Leandro Nunes de Castro
BIC 2005 - Introduction to Artificial Immune Systems - Dr. Leandro Nunes de Castro 13 ◼ Antibody Synthesis: The Immune System (IX) ... ... ... V V V library D D D library J J J library Gene rearrangement V D J Rearranged DNA after Oprea & Forrest, 1998
The Immune System X Clonal Selection and Affinity Maturation Selection Proliferation Differentiation Plasma cells Antigens BIC 2005-Introduction to artificial Immune Systems- Dr Leandro Nunes de Castro
BIC 2005 - Introduction to Artificial Immune Systems - Dr. Leandro Nunes de Castro 14 ◼ Clonal Selection and Affinity Maturation The Immune System (X) Antigens Proliferation Differentiation Plasma cells Memory cells Selection M M
The Immune System (Xn) Maturation and Cross-Reactivity of Immune Responses Primary Response Secondary Response Cross-Reactive esponse 0c Lag Response Response to Lag esponse Response Antigens Antigen Time Antigen AgI g1, Ag 15 BIC 2005-Introduction to artificial Immune Systems- Dr Leandro Nunes de Castro
BIC 2005 - Introduction to Artificial Immune Systems - Dr. Leandro Nunes de Castro 15 ◼ Maturation and Cross-Reactivity of Immune Responses The Immune System (XI) Antigen Ag1 Antigens Ag1, Ag2 Primary Response Secondary Response Lag Response to Ag1 Antibody Concentration Time Lag Response to Ag2 Response to Ag1 ... ... Cross-Reactive Response ... ... Antigen Ag1’ Response to Ag1’ Lag