The Immune System (XIn Affinity maturation somatIc hypermutation receptor editing Response BIC 2005-Introduction to artificial Immune Systems- Dr Leandro Nunes de Castro 16
BIC 2005 - Introduction to Artificial Immune Systems - Dr. Leandro Nunes de Castro 16 ◼ Affinity Maturation ◼ somatic hypermutation ◼ receptor editing The Immune System (XII) 1 ary 2 ary 3ary Affinity (log scale) Response
The Immune System (XIIr) Self /Nonself Discrimination repertoire completeness CO-stimulation tolerance Positive selection B-and T-cells are selected as immunocompetent cells Recognition of self-MHC molecules Negative selection Tolerance of self: those cells that recognize the self are eliminated from the repertoire BIC 2005-Introduction to artificial Immune Systems- Dr Leandro Nunes de Castro
BIC 2005 - Introduction to Artificial Immune Systems - Dr. Leandro Nunes de Castro 17 ◼ Self/Nonself Discrimination ◼ repertoire completeness ◼ co-stimulation ◼ tolerance ◼ Positive selection ◼ B- and T-cells are selected as immunocompetent cells ◼ Recognition of self-MHC molecules ◼ Negative selection ◼ Tolerance of self: those cells that recognize the self are eliminated from the repertoire The Immune System (XIII)