Graves Disease Pathogenesis autoimmune disorder In serum, antibodies to TSH receptor thyroid peroxisomes thyroglobulin ↑ Release of h Thyroid-stimulating immunoglobulin(TSD) Thyroid growth-stimulating immunoglobulin(TGi TSH-binding inhibitor immunoglobulins(TBlls Follicular E. proliferation
Pathogenesis: autoimmune disorder In serum, antibodies to TSH receptor thyroid peroxisomes thyroglobulin Thyroid-stimulating immunoglobulin(TSI) Thyroid growth-stimulating immunoglobulin(TGI) TSH-binding inhibitor immunoglobulins(TBIIs) Graves Disease Release of H Follicular E. proliferation
Graves Disease Pathogenesis autoimmune disorder Genetic factors HLA-B8 HLA-DR3
Pathogenesis: autoimmune disorder Genetic factors HLA-B8 HLA-DR3 Graves Disease
Graves Disease Morphology Gross: thyroid gland---diffusely enlarged Diffuse hyperplasia in a patient with Grave's disease The cut surface of the thyroid ha as a fleshy appearance
Morphology Gross: thyroid gland---diffusely enlarged. Graves Disease Diffuse hyperplasia in a patient with Grave’s disease. The cut surface of the thyroid has a fleshy appearance
diffuse symmetric enlargement beefy deep red parenchyma
diffuse symmetric enlargement beefy deep red parenchyma
Microscope: 1) hyperplastic follicles lined by tall, columnar epith. (2)crowded, enlarged epithelial cells -small papillae 3)the scalloped appearance of the edges of the colloid (follicular cells actively resorb colloid) (4)lymphoid infiltrates in interstitium, germinal center hyperplastic follicular cells small papillae d areas of colloid resor ption lymphocytes g abundant blood supply
hyperplastic follicular cells small papillae areas of colloid resorption lymphocytes abundant blood supply Microscope: (1) hyperplastic follicles lined by tall, columnar epith. (2) crowded, enlarged epithelial cells --- small papillae (3) the scalloped appearance of the edges of the colloid (follicular cells actively resorb colloid) (4) lymphoid infiltrates in interstitium, germinal center