Adults 1941年 1949年 1956年 肢端肥大症 (由1941年的正常面容,逐渐转变为1956年的曲型肺端肥大症而容) acromegaly soft tissues 满肥大症 skin VIscera bones of the face hands and feet
acromegaly soft tissues skin viscera bones of the face, hands and feet Adults
Thyroid 甲状软骨 甲状腺 气管 胸骨 锁骨
Thyroid
ypothalamus-pituitary-thyroid axis TRH: thyrotropin-releasing hormone TRH TSH thyroid-stimulating hormone TSH Pituitary TSH receptor T4: thyroxine Th id GG protein homone T3: triiodothyronine T3, T receptor GTP G void Target The net effect of t4 t3 tcAMP on t basal metabolic rate (BMR) Gene expression on
hypothalamus-pituitary-thyroid axis The net effect of T4 T3 : basal metabolic rate (BMR) TRH: thyrotropin-releasing hormone TSH: thyroid-stimulating hormone T4: thyroxine T3: triiodothyronine
Th ly1 rolc d ■ Follicles ° epithelium thyroglobulin-rich colloid Normal follicular cells
Thyroid ◼ Follicles • epithelium • thyroglobulin-rich colloid Normal follicular cells
Synthesis and storage of thyroid hormones a Thyroglobulin iodination Olloid-77 A 6. Iodination, Storage.Co Thyroglobulin reabsorption 2. Uptake of 5. Secretion iodination stored ☆ Thyroglobulin Digestion by Lysosomes lodide lysosomal s3.Endocytosis 4. Packaging lgi complex I ④ vacuoles Merge with 3b. Oxidation vesicles bearing Mannose y vi/enzymes incorporation 4. Release of Protein 3. Synthesis Synthesis of T3 and T4 from synthesis aere lysosomal 器己部 enzymes TBG lodide transporter 5. Secretion of T3 and T4 2. AA, Iodide uptake Amino acids lodide 1. Stimulation by TSH Capillary lumen
Synthesis and Storage of thyroid hormones