APC a APC can express MHC- and co-stimulatory molecules and present exogenous antigens to CD4+ T cells, besides presenting endogenous antigens to CD8+ T cells. Three cell types are classified as professional antigen-presenting cells; dendritic cells, macrophages, and B lymphocytes 特异性信号和协同刺激信号 APC MHCⅡ类分子 B7 抗原多肽 TCR-CD3复合物 CD28 T细胞 CD4T细胞活化双信号示意图
◼ APC ◼ APC can express MHC-II and co-stimulatory molecules and present exogenous antigens to CD4+ T cells, besides presenting endogenous antigens to CD8+ T cells.Three cell types are classified as professional antigen-presenting cells: dendritic cells, macrophages, and B lymphocytes
树突状细胞(DC 巨噬细胞(№φ) B细胞 1°8 抗原提呈细胞(APC)染色
1。 Dendritic cells Dendritic cells are bone marrow-derived cells Classification 造血干细胞(HSC) 淋巴样干细胞 SCF By source IL-7 L12 Myeloid DC IL-1 lL-15 SCF Lymphoid DC 髓样干细胞 B细胞 NK细胞 SCF T细胞 EPO By mature TPO 、n√ IL-3 ,G-CSF MESF 5 Immature DC 嗜碱性粒细胞 红细胞 Mature DC 血小板 o36 嗜酸性粒细胞 中性粒细胞单核巨噬细胞
1. Dendritic cells Dendritic cells are bone marrow-derived cells Classification By source Myeloid DC Lymphoid DC By mature Immature DC Mature DC
1。 Dendritic cells Dendritic cells are bone marrow-derived cells Classification Myeloid DC Lymphoid DC By mature Immature Dc Mature DC By distribution a Lymphoid tissues Interdigitating DC, follicular DC a Non-lymphoid tissues Langerhans cell ■ Body fluid
1. Dendritic cells Dendritic cells are bone marrow-derived cells Classification By source Myeloid DC Lymphoid DC By mature Immature DC Mature DC By distribution ◼ Lymphoid tissues Interdigitating DC, follicular DC ◼ Non-lymphoid tissues Langerhans cell ◼ Body fluid
滤泡树突细胞( follicular do,FDC) EDC 淋巴滤泡内的 B cells FDC通过受体N 被致敏的抗原,③ 并将其递呈给B 细胞
B cells FDC 滤泡树突细胞（follicular DC, FDC） 淋巴滤泡内的 FDC通过Fc受体 和补体受体捕获 被致敏的抗原， 并将其递呈给B 细胞