细菌抗原 (外源性抗原 内体溶酶体中( 降解的细菌 内体中的细菌 内吞 整合 转录 细菌 货得从内体脱壳 进入胞浆 翻译 病毒◎ 吸附 合成的病毒蛋白 穿入 (内源性抗原) 外源性抗原和内源性抗原的产生
细胞表面 外源性抗原 cliP 融合 晚期内体 HLA-DM 早期内体 抗原降解 高尔基体 CI类分子 内质网 APC 外源性抗原的加工及提呈过程
细胞表面 胞浆 高尔基体 2m 内质网 钙连接蛋白 TAP-1 TAP-2 MHC la链 抗原肽 蛋白酶体 之内源性抗原 内源性抗原的加工及提呈过程
The process of immune response ■ EXogenous antigens Site of infection peripheral lymphoid organ Peripheral tissue ■ Endogenous antigens Site of infection peripheral lymphoid organ Peripheral tissue
The process of immune response ◼ Exogenous antigens Site of infection peripheral lymphoid organ Peripheral tissue ◼ Endogenous antigens Site of infection peripheral lymphoid organ Peripheral tissue
Antigen-presenting cells cells that can process and present antigens(MHC peptide) to T cells Professional APc Dendritic cell Macrophage B lymphocyte nonprofessional APc Several other cell types, classified as nonprofessional antigen-presenting cells, can be induced to express class II MHc molecules or a co-stimulatory signal Many of these cells function in antigen presentation only for short periods of time during a sustained inflammatory response
Antigen-presenting cells cells that can process and present antigens (MHCpeptide) to T cells Professional APC Dendritic cell Macrophage B lymphocyte nonprofessional APC ◼ Several other cell types, classified as nonprofessional antigen-presenting cells, can be induced to express class II MHC molecules or a co-stimulatory signal Many of these cells function in antigen presentation only for short periods of time during a sustained inflammatory response