Epitope or antigen Antigenic Determinant antigen antigen
Epitope or Antigenic Determinant antigen antigen antigen
Structure of epitopes 1 Conformational epitope Nonsequential poly peptides or polysaccharide on the surface of t he molecules, Native conformation 2 liner epitope A sequential amino acid fragment, Linear determinant Inside of the antigen molecule
1 Conformational epitope Nonsequential polypeptides or polysaccharide on the surface of the molecules, Native conformation, 2 liner epitope A sequential amino acid fragment, Linear determinant, Inside of the antigen molecule Structure of epitopes
Conformational and Linear Epitope Linear Discontinuous Linear epitope Binding Discontinuous epitope Amino acid residues site for Created from amino acid are adjacent in the antigen residues located in different polypeptide chain parts of the polypeptide chain
Conformational and Linear Epitope
T cell Epitope and B cell Epitope In immune response, the epitopes that tCR and BCR recognize is different and are called t cell epitope and B cell epitope, separately. (1) human pancreatic glucagon was inoculated into the mouse (2) Production of specific antibody and T effector cell
T cell Epitope and B cell Epitope In immune response, the epitopes that TCR and BCR recognize is different, and are called T cell epitope and B cell epitope, separately. （1）human pancreatic glucagon was inoculated into the mouse 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 NH3 19 20 21 22 23 24 25 26 27 28 29 COOH （2）Production of specific antibody and T effector cell
No epito pe was found to be recognized T effector cell by T cell and B cell simultaneously aim directly at 18-29 amino acids in the c terminal NH Antigenic peptide COOH presented by APc linear antibody: aim natural determinant directly at 1-17*on the surface of the molecule amino acids in conformational or sequential determinant the n termina tertiary structure of the molecule
antibody：aim directly at 1~17 amino acids in the N terminal T effector cell： aim directly at 18~29 amino acids in the C terminal No epitope was found to be recognized by T cell and B cell simultaneously. *natural, *on the surface of the molecule * conformational or sequential determinant * tertiary structure of the molecule COOH 1 2 3 4 5 6 7 8 9 10 11 12 13 1415 16 17 18 NH3 19 20 21 22 23 24 25 26 27 28 29 * Antigenic peptide presented by APC * linear determinant