(2) 0X-LDLDNot berecognized by nativeLDLreceptor②Engulfmediateby scavengerreceptor(Mosurface) →foam cellChemotactic to monocytesT+)ChemotactictoEC、SMCT?GF个
(2) ox-LDL ① Not be recognized by native LDL receptor ② Engulf mediate by scavenger receptor (Mφsurface）→foam cell ③ Chemotactic to monocytes↑ ④ Chemotactic to EC、SMC↑ ⑤ GF ↑
Hyperlipidemia,Hypertension.Smoking,Toxins,Hemodynamicfactors,lmmunereactions.VirusesEndothelial Injury/DysfunctionMonocyteadhesionandCholesterol effluxvia HDlemigrationinto intimaLumenExtracellulatmatrixsynthesisLDLMacrophageEndotheliumProliferationofFoamLipidsmooth.muscleLDLcellsCytokinesuptakecells(e.g..IL-1.MCP-1)IntimaOxidizedLDLExtracellularlipicCytokines/GrowthFactorsand necroticcellInternalMigrationofelasticsmoothmusclecellsmembraneSmoothmusclecellsMedia+ProgressivedevelopmentofNormalvesselartheroscleroticplaque
二. MorphologyFavoritesite:lowerabdominalaortacoronarypoplitealAdescending thoracic aortainternal carotidAvessels of circle of willis
二. Morphology (一) Favorite site: lower abdominal aorta coronary A popliteal A descending thoracic aorta internal carotid A vessels of circle of willis
(二)Basic pathologic changesFATTYSTREAKFIBROUS PLAQUECOMPLICATEDLESION
(二) Basic pathologic changes
1. Fatty streak: the early lesion(1) Gross: yellow flat spots or streaks1-2mm in width, slightly raisedNORMALINTIMAFatty spotFATTYSTREAK
1. Fatty streak: the early lesion (1) Gross: yellow flat spots or streaks, 1-2mm in width , slightly raised Fatty spot