1. Migration of smooth2. Smooth muscle3.Elaboration ofmuscle cells to thecellmitosisextracellularEndotheliumintimamatrixIntimaInternalelasticlaminaSmoothMediamusclecells
EndothaliaIntimeModiaAdvantii1-Chranitondotholia"iniury":yperhpidomiaHyprnionsmokingHomooyetcinoHamadynamictactorsToxinaHosDonotoinjury-Viruaos1immunoroaotiontCz,tnratholaldyotunotion(a.aincreasodpermeabiity,loukocytaadnsian)MonooyteadheaionHne omiarations,moothmueoloarniartonfrommodiatointima.Maerophianaativation,trk4MactophagosandarnootntnusacelisongulflipidLymphocytFibrotatyatharoma5.Smoouhmuatleprolroration.collagenandoihorECMLipiddopoaitionxtirscelulardobrisHpidLyrnphoayteColaaan
2. Lipid infiltration hypothesis HyperlipidemiaEC damage→permeability↑lipoprotein deposit→MpcleanupSMCTAtheroma
2. Lipid infiltration hypothesis ： Hyperlipidemia ↓ EC damage→permeability↑ →lipoprotein deposit→Mφcleanup ↓ SMC↑ ↓ Atheroma
3. Smooth muscle mutagenic hypothesis1)SMC in AS plaque→monocloneCauses:chemical mutagenic agentsvirus
3. Smooth muscle mutagenic hypothesis ① SMC in AS plaque→monoclone ② Causes: chemical mutagenic agents virus
4. Macrophage receptor defect hypothesis(1) Normal Cell membrane:LDLreceptorcombine withLDL→engulfintracellularIntake-LDLreceptor-→change with the needofcholesterol(2) AS: LDL receptors↓↓→LDL cleaning)LDLinblood
4. Macrophage receptor defect hypothesis (1) Normal ① Cell membrane: LDL receptor→combine with LDL→engulf→intracellular ② Intake→LDL receptor→change with the need of cholesterol (2) AS: LDL receptors↓↓→LDL cleaning↓ →LDL in blood↑