Molecular Imaging and Genomics Radiology Dept, Ruijin Hospital SSMU
Molecular Imaging and Genomics Radiology Dept. , Ruijin Hospital SSMU
Technology development to spearhead the revolution in medicine Radiology Imageology Molecular Imaging Genomics and Molecular ima
G e n o m i c s a n d M o l e c u l a r I m a g i n g Molecular Imaging Imageology Radiology Technology development to spearhead the revolution in medicine…
Molecular Imaging Components tic Pha PET MRL MRSI Biochemistry Novel agents/tracers DNA/Protein MicroArrays Diagnosti Tuvajev, Blasberg Larson MSKcC Biotech Imaging Physics, MOLECULAR Molecular Engineering IMAGING Core Technologies Integrated Diagnostics 2. Image Analysis ivo Imaging tie rugs needing more specific disease diagnosis to Applied Genomics genetic data on patient Chemistry libraries Pharmacology armaceuticals Integrating Critical Skills. Imaging with Diagnostics. Diagnostics with Therapeutics
G e n o m i c s a n d M o l e c u l a r I m a g i n g DNA/Protein MicroArrays Affymetrix Integrated Diagnostics: in Vivo Imaging tied to Applied Genomics Molecular Imaging Components Source: Uzgiris, GE CRD Tjuvajev, Blasberg, Larson, MSKCC Drugs needing more specific disease diagnosis or genetic data on patient Chemistry libraries Novel agents/tracers Biochemistry Pharmacology MOLECULAR IMAGING Molecular Biology PET, MRI, MRSI Core Technologies: 1. Hi Sens/Spec Imaging 2. Image Analysis Imaging Physics, Engineering Integrating Critical Skills… Imaging with Diagnostics … Diagnostics with Therapeutics
Broad Based Technology Platform Approach Fundamental Technology Hurdles Platform Concepts Project Disease Targets Definition Industry and Academic Partnerships Technology Focus Areas: MR and pet diagnostic agent Biomarker Discovery and Clinical IVD Biomedical Informatics and Computing Clinical Translation and Imaging Optimization Optical Imaging Genomics and Molecular i magi n
G e n o m i c s a n d M o l e c u l a r I m a g i n g • Fundamental Technology Hurdles • Platform Concepts • Disease Targets • Industry and Academic Partnerships Project Definition Technology Focus Areas: • MR and PET Diagnostic Agents • Biomarker Discovery and Clinical IVD • Biomedical Informatics and Computing • Clinical Translation and Imaging Optimization • Optical Imaging Broad Based Technology Platform Approach
Molecular tools Disease Specific Metrics Anatomical Compartments (Blood, Lipophilic Tissue(fat) letabolic Active(muscle), Elimination(liver, kidney)…) Physio-chemical (Metabolism, Oxygenation, Diffusion, pH, Transport Characteristics, Elimination Phagocytosis, Cell-type Specific.) Biological (Cell Surface Receptors, Antigens, Transporters, Gene Sequences, Proteins, Enzymatic Activity Post Translational Modification.) Vulnerable Plaque Imaging Molecula Molecular Imaging: Pathology Specific Molecular Markers
G e n o m i c s a n d M o l e c u l a r I m a g i n g Molecular Tools Compartments (Blood, Lipophilic Tissue (fat), Metabolic Active (muscle), Elimination (liver, kidney)…) Physio-chemical (Metabolism, Oxygenation, Diffusion, pH, Transport Characteristics, Elimination, Phagocytosis, Cell-type Specific…) Biological (Cell Surface Receptors, Antigens, Transporters, Gene Sequences, Proteins, Enzymatic Activity, Post Translational Modification…) Anatomical Molecular Molecular Imaging: Pathology Specific Molecular Markers Disease Specific Metrics Vulnerable Plaque Imaging