II. Percutaneous absorption enhancers There is great interest among pharmaceutical scientists to develop chemical permeation enhancers and physical methods that can increase percutaneous absorption of therapeutic agents
II. Percutaneous absorption enhancers There is great interest among pharmaceutical scientists to develop chemical permeation enhancers and physical methods that can increase percutaneous absorption of therapeutic agents
Chemical enhancers A chemical skin penetration enhancer increases skin permeability by reversibly damaging or altering the physicochemical nature of the stratum corneum to reduce its diffusional resistance 化学吸收促进剂通过通过可逆地改变角质 层的理化状态,降低扩散阻力而提高皮肤 渗透率
1. Chemical enhancers A chemical skin penetration enhancer increases skin permeability by reversibly damaging or altering the physicochemical nature of the stratum corneum to reduce its diffusional resistance. 化学吸收促进剂通过通过可逆地改变角质 层的理化状态，降低扩散阻力而提高皮肤 渗透率
Increased hydration of the stratum corneum solvent action or denaturation A change in the structure of the lipids and lipoproteins in the intercellular channels
Increased hydration of the stratum corneum A change in the structure of the lipids and lipoproteins in the intercellular channels solvent action or denaturation
More than 275 chemical com pounds have been cited in the literature as skin penetration enhancers; they include o acetone,aone(氮酮), dimethyl acetamide(二甲基乙酰胺), dimethy1 formamide(二甲基甲酰胺), dimethyl sulfoxide(DMSO),二甲基亚砜 ethanol, oleic acid,油酸 polyethylene glycol, propylene glycol(丙二醇) sodium lauryl sulfate(月桂醇硫酸钠)
More than 275 chemical compounds have been cited in the literature as skin penetration enhancers; they include acetone, azone （氮酮）, dimethyl acetamide （二甲基乙酰胺）, dimethyl formamide（二甲基甲酰胺）, dimethyl sulfoxide (DMSO), 二甲基亚砜 ethanol, oleic acid, 油酸 polyethylene glycol, propylene glycol （丙二醇）, sodium lauryl sulfate （月桂醇硫酸钠）
The selection of a permeation enhancer should be based on its efficacy in enhancing skin permeation ■ its dermal toxicity a its physicochemical and biologic compatibility with the systems other components
The selection of a permeation enhancer should be based on ◼ its efficacy in enhancing skin permeation ◼ its dermal toxicity ◼ its physicochemical and biologic compatibility with the system’s other components