I Factors affecting percutaneous absorption 1. Drug concentration is an important factor (药物浓度是一个重要因素。) 2. The larger the area of application, the more drug is absorbed. (当药物应用面积增大,经皮吸收的药物量 增加。)
I. Factors affecting percutaneous absorption 1. Drug concentration is an important factor. （药物浓度是一个重要因素。） 2. The larger the area of application, the more drug is absorbed. （当药物应用面积增大，经皮吸收的药物量 增加。）
3. The aqueous solubility of a drug determines the concentration presented to the absorption site, and the partition coefficient influences the rate of transport across the absorption site 药物的水溶性决定了吸收部位的浓度,分配系 数影响吸收部位的药物转运速率。 Drugs generally penetrate the skin better in their un-ionized form. Nonpolar drugs tend to across the cell barrier through the lipid-rich regions, whereas the polar drugs favor transport between ces。 料跨牌的橙跨邀翻随走极精额栓磊拐 非 过 则通过细胞转运
3. The aqueous solubility of a drug determines the concentration presented to the absorption site, and the partition coefficient influences the rate of transport across the absorption site. 药物的水溶性决定了吸收部位的浓度，分配系 数影响吸收部位的药物转运速率。 Drugs generally penetrate the skin better in their un-ionized form. Nonpolar drugs tend to across the cell barrier through the lipid-rich regions, whereas the polar drugs favor transport between cells. 非解离型的药物透皮效果好。非极性药物易通 过富含脂质的部位跨越细胞屏障，而极性药物 则通过细胞转运
4. Drugs with molecular weights of 100 to 800 and adequate lipid and aqueous solubility can permeate skin. Ihe ideal molecular weight of a drug for transdermaldrug delivery is believed to be 400 or less 分子量在100和800之间并且具有一定的 脂溶性和水溶性的药物能渗透入皮肤。理 想的经皮吸收系统的药物分子量应为400 或更小
4. Drugs with molecular weights of 100 to 800 and adequate lipid and aqueous solubility can permeate skin. The ideal molecular weight of a drug for transdermal drug delivery is believed to be 400 or less. 分子量在100和800之间并且具有一定的 脂溶性和水溶性的药物能渗透入皮肤。理 想的经皮吸收系统的药物分子量应为400 或更小
5. Hydration of the skin generally favors percutaneous absorption. The TDDS acts as an occlusive moisture barrier through which sweat cannot pass, increasing skin hydration 皮肤的水和作用通常有利于经皮吸收 TDDS可以作为隔绝湿气的屏障(汗水不能 通过),使皮肤水合化程度增加
5. Hydration of the skin generally favors percutaneous absorption. The TDDS acts as an occlusive moisture barrier through which sweat cannot pass, increasing skin hydration. 皮肤的水和作用通常有利于经皮吸收。 TDDS可以作为隔绝湿气的屏障（汗水不能 通过），使皮肤水合化程度增加
6. Percutaneous absorption appears to be greater when the TDDs is applied to a site with a thin horny laver than with a thick one TDDS在角质层薄的部位比角质层厚的部位 经皮吸收好。 7. Generally, the longer the medicated application is permitted to remain in contact with the skin, the greater is the total drug absorption 一般而言,药物应用的时间越长,即与皮肤 接触时间越长,药物吸收总量越多
6. Percutaneous absorption appears to be greater when the TDDS is applied to a site with a thin horny layer than with a thick one. TDDS在角质层薄的部位比角质层厚的部位 经皮吸收好。 7. Generally, the longer the medicated application is permitted to remain in contact with the skin, the greater is the total drug absorption. 一般而言，药物应用的时间越长，即与皮肤 接触时间越长，药物吸收总量越多