Helicobacterpylori Helicobacter pylori is the prototype organism in this group. It is associated with antral gastritis, gastric ulcers, and gastric carcinoma
Helicobacter pylori Helicobacter pylori is the prototype organism in this group. It is associated with antral gastritis, gastric ulcers, and gastric carcinoma
Microbiolog e Gram negative rod curved eVery motile> corkscrew motion Microaerophilic, use amino acids and fatty acids rather than carbohydrates to obtain energy needs 10%CO2 and 5%O2 Urease production e Catalase production .Oxidase positive 2 a Growth at 370C. not 250C or 420C
Microbiology Gram negative rod, curved, Very Motile → corkscrew motion Microaerophilic, use amino acids and fatty acids rather than carbohydrates to obtain energy needs 10% CO2 and 5% O2 Urease production Catalase production Oxidase positive Growth at 370C, not 250C or 420C
Virulence factors e vacA(vacuolating associated cytotoxin, Pathogenicity island: cag, cytotoxin associated gene A+genes related to bacterial secretion e Cag* HP is much more associated with peptic ulcer disease than Cag(-) HP
Virulence factors vacA (vacuolationg associated) cytotoxin, Pathogenicity island: cag, cytotoxin associated gene A+genes related to bacterial secretion Cag+ HP is much more associated with peptic ulcer disease than Cag(--) HP
HP+ 1%p日 duodenal uilcer gastric ulcer tric lymp phom Hric cancer
Pathogenesis Acidic Gastric Juice mOtility -it moves into the mucus and produces adhesins on gastric epithelial cells H=2 (not intestinal epithelial cells) uRease production breaks down pH=4 the urea to ammonia which buffers ucus gel layer the ph around the bacterium HC○3NH pErsists, escape defense mechanisms- SOD, catalase PH=7 Pylon Urease. Breack down free radicals nucusicells
Pathogenesis Motility – it moves into the mucus and produces adhesins on gastric epithelial cells (not intestinal epithelial cells) Urease production, breaks down the urea to ammonia which buffers the pH around the bacterium. Persists, escape defense mechanisms – SOD, catalase, Urease. Breack down free radicals