Molecular weight distribution of the Nmr structures deposited in the brookhaven PDB as of December 1997 100 方60 乏z 40 Gunter P Q Rev Biophys, 31145-237(1998) Molecular weight(kDa) YAN
Molecular weight distribution of the NMR structures deposited in the Brookhaven PDB as of December 1997. Guntert P. Q Rev Biophys, 31:145-237 (1998). THNMR YAN
1.3 Great contributions to biology solution structures at atomic re solution in semi- physiological conditions dynamic properties and the properties of part ally folded or unfolded proteins weak interactions between macromolecules and ligands a practical approach to arug design Ref: WagnerG. Nature Structural Biology. 4: 841-844 (1997) THNMR AN
1.3 Great contributions to biology solution structures at atomic resolution in semiphysiological conditions dynamic properties and the properties of partially folded or unfolded proteins weak interactions between macromoloecules and ligands a practical approach to drug design Ref: Wagner G. Nature Structural Biology. 4: 841-844 (1997) THNMR YAN
1. 4 Milestones NMR 1946-the first spectra of solid compounds 1957-the first spectra of a protein -Rnase a 1982 -the first protein spectra was assigned 1985-the first solution structure of a protein 1997-924 NMR structures in Pdb Today -over 2, 378 structures in PDB X-ray 1913-the first diffraction patterns of crystals were reported 1934-the first protein crystallized and examined-pepsin 1960-the first protein crystal structures- myoglobin, hemoglobin 1997-5012 crystals structures in PDB Today-over 12, 780 structures in PDB THNMR Ref: WagnerG. Nature Structural Biology. 4: 841-844 (1997) AN PBD ANNUAL REPORT 2001
1.4 Milestones NMR 1946 - the first spectra of solid compounds 1957 - the first spectra of a protein - RNase A 1982 - the first protein spectra was assigned 1985 - the first solution structure of a protein 1997 - 924 NMR structures in PDB Today - over 2,378 structures in PDB X-ray 1913 - the first diffraction patterns of crystals were reported 1934 - the first protein crystallized and examined - pepsin 1960 - the first protein crystal structures - myoglobin, hemoglobin 1997 - 5012 crystals structures in PDB Today - over 12,780 structures in PDB Ref: Wagner G. Nature Structural Biology. 4: 841-844 (1997) PBD ANNUAL REPORT, 2001 THNMR YAN
1. 4 Milestones X-ray 25 years older than NMr more order more mature NMR: still in a developmental stage major improvements are still being made Incomplete view using only one single techniques Ref: WagnerG. Nature Structural Biology. 4: 841-844(1997) THNMR AN
1.4 Milestones X-ray: 25 years older than NMR • more order, more mature NMR: still in a developmental stage • major improvements are still being made Incomplete view using only one single techniques Ref: Wagner G. Nature Structural Biology. 4: 841-844 (1997) THNMR YAN