Cellular swelling O Gross:when it affects many cells,it causes pallor,increase in size and weight of the affected organ,and loss of normal glistening translucence -“boiled meat”appearance O Microscope:The parenchyma cells are enlarged in various degrees and crowded together,and the cytoplasm is translucent and stains more lightly
Cellular swelling Gross: when it affects many cells, it causes pallor, increase in size and weight of the affected organ, and loss of normal glistening translucence – “boiled meat” appearance Microscope: The parenchyma cells are enlarged in various degrees and crowded together, and the cytoplasm is translucent and stains more lightly
Ballooning change (hydropic degeneration) in hepatocytes
Ballooning change (hydropic degeneration) in hepatocytes
w√Fatty change Abnormal accumulation of triglycerides within parenchymal cells o In hypoxic injury and in various forms of toxic or metabolic injury Manifested by the appearance of small or large lipid vacuoles in the cytoplasm
Fatty change Abnormal accumulation of triglycerides within parenchymal cells In hypoxic injury and in various forms of toxic or metabolic injury Manifested by the appearance of small or large lipid vacuoles in the cytoplasm
1.Fatty liver --Causes of fatty liver Accumulation of triglycerides in the cytoplasm of liver cells occurs in the following conditions: (1)When there is increased mobilization of adipose tissue; (2)When the rate of conversion of fatty acids to triglycerides is increased; (3)When oxidation of triglycerides to acetyl-CoA and ketone bodies is decreased; (4)When synthesis of lipid acceptor proteins is deficient
1. Fatty liver --- Causes of fatty liver Accumulation of triglycerides in the cytoplasm of liver cells occurs in the following conditions: (1) When there is increased mobilization of adipose tissue; (2) When the rate of conversion of fatty acids to triglycerides is increased; (3) When oxidation of triglycerides to acetyl-CoA and ketone bodies is decreased; (4) When synthesis of lipid acceptor proteins is deficient
Fatty liver Morphological changes Gross:Enlarged and yellow,with a greasy appearance when cut Microscope:Fat droplets in the cytoplasm fuse to form progressively larger globules (macrovacuolar fatty changes)
Fatty liver --- Morphological changes Gross: Enlarged and yellow, with a greasy appearance when cut Microscope: Fat droplets in the cytoplasm fuse to form progressively larger globules (macrovacuolar fatty changes)