15.6 Friedel-Crafts alkylation 付瑞德尔克拉夫茨烷基化 a general equation for a Friedel Crafts alky lation reaction is the following AICI R R—X hX CH CH Cl AlCs CH3 hX
15.6 Friedel-Crafts alkylation 付瑞德尔-克拉夫茨烷基化 A general equation for a FriedelCrafts alkylation reaction is the following: + R X AlCl 3 R + HX + Cl AlCl 3 CH + HX CH3 CH3
The mechanism for this reaction Step c+AC3一 t AICl Isopropyl Chloride Step2 Carbocation Arenium ion CH3 CH Step3 CH3 hX Arenium ion Isopropylbenzene 异丙苯
The mechanism for this reaction Cl AlCl Step1 + 3 + + AlCl 4 - Isopropyl Chloride Step2 + + + H Carbocation Arenium ion CH + HX CH3 S CH3 tep3 H + Arenium ion Isopropylbenzene 异 丙 苯
More friedel-Crafts alkylation CH O°C CH3CH=CH HE CH Isopropylbenzene 异丙苯(84号) 0°C HF Cyclohexene Cyclohexylbenzene环已基苯 (62%) 60°C HO BF Cyclohexanol Cyclohexylbenzene (56%
More Friedel-Crafts alkylation Isopropylbenzene 异 丙 苯 (84%) + CH3CH=CH2 O oC HF CH3 CH3 + O oC HF Cyclohexene Cyclohexylbenzene 环 己 基 苯 (62%) + 60 oC BF3 Cyclohexanol Cyclohexylbenzene (56%) HO
15.7 Friedel-Crafts Acylation 付瑞德尔-克拉夫茨酰基化 AICI3 t chical excess benzene CH3 cetophene (methyl phenyl ketone) 苯乙酮 (97%) AICI3 Phcc Diphenyl ketone 二苯甲酮
15.7 Friedel-Crafts Acylation 付瑞德尔-克拉夫茨酰基化 Acetophene (methyl phenyl ketone) 苯 乙 酮 (97%) + CH3CCl excess benzene O CH3 O AlCl 3 Diphenyl ketone 二 苯 甲 酮 + PhCCl C O O AlCl 3
Friedel- Crafts acylations can also be carried out using carboxylic acid anhydrides (酸酐) H3C AlCl3 c—cH CH3COOH Acetophenone Acetic anhydride methyl phenyl ketone) 苯乙酮 乙酐 (82-85%)
Friedel-Crafts acylations can also be carried out using carboxylic acid anhydrides （酸酐）. Acetophenone (methyl phenyl ketone) 苯乙酮 (82-85%) + C O AlCl CH3 3 H3C O O H3C O Acetic anhydride 乙 酐 + CH3COOH