DNA REPLICATION 0 DNA Duplicates Informati DNA Information TRANSCRIPTION RNA Synthesis 00 RNA mRNA Cytoplasm Information Nuclear Envelope TRANSLATION Protein Synthesis Ribosome Protein Protein Image by MIT OCW
Image by MIT OCW. DNA DNA RNA Protein Nuclear Envelope Information Ribosome Protein TRANSLATION Protein Synthesis TRANSCRIPTION RNA Synthesis Cytoplasm Nucleus REPLICATION DNA Duplicates Information Information mRNA
The central dogma defines three major groups of biomolecules(biopolymers) DNa (passive library, 6x109 bp, 2 m/cell 75x1012 cells/human total length 150x1012m/human -1000 sun-earth) 2 RNA (passive'intermediate) Proteins(active work horses) The fourth(and final) group consists of So-called 'small molecules 4. Small molecules(sugars, hormones vitamines, 'substrates'etc
The central dogma defines three major groups of biomolecules (biopolymers): 1. DNA (passive library, 6×10 9 bp, 2 m/cell, 75×1012 cells/human, total length 150×1012 m/human ~ 1000 rsun-earth ) 2. RNA (‘passive’ intermediate) 3. Proteins (active work horses) The fourth (and final) group consists of so-called ‘small molecules’. 4. Small molecules (sugars, hormones, vitamines, ‘substrates’ etc.)
The lysis-lysogeny decision As the phage genome is injected phage genes are transcribed and translated by using the host's machinery Which set of phage proteins are expressed determines the fate of the nage: lysis or lysogeny Q UV Induction Lysis Image by MIT OCW
The lysis-lysogeny decision: As the phage genome is injected phage genes are transcribed and translated by using the host’s machinery. Which set of phage proteins are expressed determines the fate of the phage: lysis or lysogeny Image by MIT OCW
The lysis-lysogeny decision is a genetic switch ←c cl transcript N然然四然然然 17 bp cro transcrip RNAp RNAp N欢然NNN公 Image by MIT oCW. After Ptashne, Mark. A genetic switch: phage lambda. 3rd ed. Cold Spring Harbor, NY Cold Spring Harbor Laboratory Press, 2004
The lysis-lysogeny decision is a genetic switch Image by MIT OCW. After Ptashne, Mark. A genetic switch : phage lambda. 3rd ed. Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, 2004
Single repressor dimer bound -three cases Negative control, dimer binding to OR2 inhibits RNAp binding to right PR promoter Positive control, dimer binding to OR2 enhances RNAp binding to left PRM promoter Image removed due to copyright considerations See Ptashne, Mark. A genetic switch: phage lambda 3rd ed. Cold Spring Harbor, N.Y. Cold Spring Harbor Laboratory Press, 2004
Single repressor dimer bound - three cases: I Negative control, dimer binding to OR2 inhibits RNAp binding to right PR promoter. Positive control, dimer binding to OR2 enhances RNAp binding to left PRM promoter. Image removed due to copyright considerations. See Ptashne, Mark. A genetic switch: phage lambda. 3rd ed. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press, 2004