Wrapping up E coli chemotaxis (L7& L8) Main points of last 2 lectures L7: Biological background what is the function of the individual molecules L8: modeling of all possible chemotactic reactions why doesn't this model reproduce experimentally observed perfect adaptation L8-9: strip down full model to essentials based on assumptions that are experimentally justified (or sometimes not
Wrapping up E. coli Chemotaxis (L7 & L8) Main points of last 2 lectures: L7: Biological background what is the function of the individual molecules ? L8: modeling of all possible chemotactic reactions why doesn’t this model reproduce experimentally observed perfect adaptation ? L8-9: strip down full model to essentials based on assumptions that are experimentally jus tified (or sometimes not) reduction 1
Figure 1A in Mittal, N, E.O. Budrene M. P. Brenner, and A. van oudenaarden Motility of Escherichia coli cells in clusters formed by chemotactic aggregation. "Proc Nat/ Acad SciUSA 100,no.23(NoV11,2003):13259-63 Copyright(2003)National Academy of Sciences, U.S.A
100, no. 23 (Nov 11, 2003): 13259-63. Copyright (2003) National Academy of Sciences, U. S. A. Figure 1A in Mittal, N., E. O. Budrene, M. P. Brenner, and A. Van Oudenaarden. "Motility of Escherichia coli cells in clusters formed by chemotactic aggregation." Proc Natl Acad Sci U S A
Images removed due to copyright considerations
Images removed due to copyright considerations. 3
Absence of chemical attractant Tumble Run Image by MIT OCW
Absence of chemical attractant 4 Image by MIT OCW. Tumble Run
Presence of chemical attractant Attractant Tumble Run Chemical Gradient Sensed in a Temporal manner Image by MIT OCW
Presence of chemical attractant 5 Image by MIT OCW. Tu m ble C h e mic al Gra die nt S e n s e d in a Te m p oral M a n n er R u n Attracta nt