Contents Part II Biomedical Informatics Applications 12 Electronic Health Record Systems 391 Clement J. McDonald, Paul C. Tang, and George Hripcsak 13 Health Information Infrastructure William A. Yanoff 14 Management of Information in Health Care Organizations Lynn Harold Vogel 15 Patient-Centered Care Systems 475 Judy Ozbolt, Suzanne Bakken, and Patricia C Dykes 16 Public health informatics Martin la venture. david a. ross. and william a. yasnoff 17 Consumer health Informatics and personal Health Records 517 vin Johnson, Holly Brugge and Kenneth D. mandl 18 Telehealth Justin B Starren, Thomas S Nesbitt, and Michael F. chiang 19 Patient Monitoring Systems 561 Reed M. Gardner, Terry P. Clemmer, R. Scott Evans, and Roger G. Mark 20 Imaging Systems in Radiology Bradley Erickson and Robert A Greenes 21 Information retrieval and digital libraries 613 William R. hersh 22 Clinical Decision-Support Systems 643 Mark A. Musen. Blackford Middleton. and Robert A greenes Computers in Health Care Education 675 Parvati Dev and Titus K L. Schleyer 24 Bioinformatics Sean D. Mooney, Jessica D. Tenenbaum, and Russ B. Altman 25 Translational bioinformatics 721 Jessica D Tenenbaum, Nigam H Shah, and Russ B. Altman 26 Clinical research informatics lip R.O. Payne, Peter J. Embi, and James J. Cimino
xx Part II Biomedical Informatics Applications 12 Electronic Health Record Systems . . . . . . . . . . . . . . . . . . . . . . . 391 Clement J. McDonald, Paul C. Tang, and George Hripcsak 13 Health Information Infrastructure . . . . . . . . . . . . . . . . . . . . . . . 423 William A. Yasnoff 14 Management of Information in Health Care Organizations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 443 Lynn Harold Vogel 15 Patient-Centered Care Systems . . . . . . . . . . . . . . . . . . . . . . . . . . 475 Judy Ozbolt, Suzanne Bakken, and Patricia C. Dykes 16 Public Health Informatics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 503 Martin LaVenture, David A. Ross, and William A. Yasnoff 17 Consumer Health Informatics and Personal Health Records . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 517 Kevin Johnson, Holly Brugge Jimison, and Kenneth D. Mandl 18 Telehealth . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 541 Justin B. Starren, Thomas S. Nesbitt, and Michael F. Chiang 19 Patient Monitoring Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 561 Reed M. Gardner, Terry P. Clemmer, R. Scott Evans, and Roger G. Mark 20 Imaging Systems in Radiology . . . . . . . . . . . . . . . . . . . . . . . . . . . 593 Bradley Erickson and Robert A. Greenes 21 Information Retrieval and Digital Libraries . . . . . . . . . . . . . . . 613 William R. Hersh 22 Clinical Decision-Support Systems . . . . . . . . . . . . . . . . . . . . . . . 643 Mark A. Musen, Blackford Middleton, and Robert A. Greenes 23 Computers in Health Care Education . . . . . . . . . . . . . . . . . . . . . 675 Parvati Dev and Titus K.L. Schleyer 24 Bioinformatics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 695 Sean D. Mooney, Jessica D. Tenenbaum, and Russ B. Altman 25 Translational Bioinformatics . . . . . . . . . . . . . . . . . . . . . . . . . . . . 721 Jessica D. Tenenbaum, Nigam H. Shah, and Russ B. Altman 26 Clinical Research Informatics . . . . . . . . . . . . . . . . . . . . . . . . . . . 755 Philip R.O. Payne, Peter J. Embi, and James J. Cimino Contents
Contents XXI Part Ii Biomedical Informaties in the Years ahead 27 Health Information Technology Policy 781 Robert s Rudin, Paul C. Tang, and David w. Bates 28 The Future of Informatics in Biomedicine 797 Mark e. frisse. Valerie Florance. Kenneth D. mandl sarv 813 Bibliography 865 Name index Subject Inde
xxi Part III Biomedical Informatics in the Years Ahead 27 Health Information Technology Policy . . . . . . . . . . . . . . . . . . . . 781 Robert S. Rudin, Paul C. Tang, and David W. Bates 28 The Future of Informatics in Biomedicine . . . . . . . . . . . . . . . . . 797 Mark E. Frisse, Valerie Florance, Kenneth D. Mandl, and Isaac S. Kohane Glossary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 813 Bibliography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 865 Name Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 927 Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 943 Contents
Contributors Russ B. Altman, MD, PhD, FACMI Departments of Bioengineering, Genetics and Medicine, Stanford University, Stanford, CA, USA Suzanne Bakken, RN, PhD, FAAN, FACMI Department of Biomedical Informatics, School of Nursing, Columbia University, New York, NY, USA G. Octo Barnett, MD, FACP, FACMI Laboratory of Computer Science (Harvard Medical School and Massachusetts General Hospital) David w. Bates, MD, MSc, FACMI Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Womens Hospital, Boston, MA, USA James F. Brinkley, MD, PhD, FACMI Department of Biological Structure, Biomedical Education and Medical Education, Computer Science and Engineering, University of Washington, Seattle, WA, USA Michael F. Chiang, MD, MA Department of Ophthalmology and Medical Informatics and Clinical Epidemiology, Oregon Health Science University, Portland, OR, USA James J. Cimino, MD, FACMI Laboratory for Informatics Development, NIH Clinical Center. Bethesda. MD. USA Terry P. Clemmer. MD Pulmonary-Critical Care Medicine LDS Hospital, Salt Lake City, UT, USA Reid Cushman, PhD Department of Medicine, University of Miami, Miami FL USA Parvati Dev, PhD, FACMI Innovation in Learning Inc., Los Lotos Hills, CA USA Patricia C Dykes, DNSC, MA, FACMI Center for Patient Safety Research and Practice, Brigham and Women's Hospital, Boston, MA, USA Noemie Elhadad, PhD Department of Biomedical Informatics, Columbia University, New York, NY, USA Peter J Embi, MD, MS, FACMI Departments of Biomedical Informatics and Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA
xxiii Contributors Russ B. Altman , MD, PhD, FACMI Departments of Bioengineering, Genetics and Medicine , Stanford University , Stanford , CA , USA Suzanne Bakken , RN, PhD, FAAN, FACMI Department of Biomedical Informatics , School of Nursing, Columbia University , New York , NY , USA G. Octo Barnett , MD, FACP, FACMI Laboratory of Computer Science (Harvard Medical School and Massachusetts General Hospital) , Boston , MA , USA David W. Bates , MD, MSc, FACMI Division of General Internal Medicine and Primary Care, Department of Medicine , Brigham and Women’s Hospital , Boston , MA , USA James F. Brinkley , MD, PhD, FACMI Department of Biological Structure, Biomedical Education and Medical Education, Computer Science and Engineering , University of Washington , Seattle , WA , USA Michael F. Chiang , MD, MA Department of Ophthalmology and Medical Informatics and Clinical Epidemiology , Oregon Health & Science University , Portland , OR , USA James J. Cimino , MD, FACMI Laboratory for Informatics Development , NIH Clinical Center , Bethesda , MD , USA Terry P. Clemmer , MD Pulmonary – Critical Care Medicine , LDS Hospital , Salt Lake City , UT , USA Reid Cushman , PhD Department of Medicine , University of Miami , Miami , FL , USA Parvati Dev , PhD, FACMI Innovation in Learning Inc. , Los Alotos Hills , CA , USA Patricia C. Dykes , DNSc, MA, FACMI Center for Patient Safety Research and Practice , Brigham and Women’s Hospital , Boston , MA , USA Noémie Elhadad , PhD Department of Biomedical Informatics , Columbia University , New York , NY , USA Peter J. Embi , MD, MS, FACMI Departments of Biomedical Informatics and Internal Medicine , The Ohio State University Wexner Medical Center , Columbus , OH , USA
Contribu Bradley Erickson, MD, PhD Department of Radiology and Medical Informatics, Mayo Clinic, Rochester, MN, USA R. Scott Evans, BS, MS, PhD, FACMI Medical Informatics Department, LDS Hospital, Intermountain Healthcare, Salt Lake City, UT, USA Valerie Florance, PhD, FACMI Division of Extramural Programs National Library of Medicine, National Institutes of Health, DHHS, Bethesda. MD. USA lan T. Foster, PhD Searle Chemistry Laboratory, Computation Institute University of Chicago and Argonne National Laboratory, Chicago, IL, USA Carol Friedman, PhD, FACMI Department of Biomedical Informatics, Columbia University, New York, NY, USA Charles P. Friedman, PhD, FACMI Schools of Information and Public Health, University of Michigan, Ann Arbor, MI, USA Mark E Frisse, MD, MS, MBA, FACMI Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA Reed M. Gardner, PhD, FACMI Department of Informatics University of Utah, Biomedical Informatics, Salt Lake City, UT, USA Kenneth w. Goodman, PhD, FACMI University of Miami Bioethics Program, Miami, FL, USA Robert A Greenes, MD, PhD, FACMI Department of Biomedical Informatics, Arizona State University, Tempe, AZ, USA Division of Health Sciences Research, College of Medicine, Mayo Clinic, Scottsdale, AZ, USA Hayit Greenspan, PhD Department of Biomedical Engineering. Faculty of Engineering, TelAviv University, Tel Aviv, Israe W. Edward Hammond, PhD, FACMI Duke Center for Health Informatics, Duke University Medical Center, Durham, NC, USA william R Hersh, MD FACMI, FACP Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, USA George Hripcsak, MD, MS, FACMI Department of Biomedical Informatics, Columbia University Medical Center, New York, NY, USA Stanley M. Huff, MD, FACMI Medical Informatics, intermountain Healthcare, Murray, UT, USA Charles Jaffe PhD Health Level Seven International Del Mar, CA, USA Holly Brugge Jimison, PhD, FACMI Consortium on Technology for Proactive Care, Colleges of Computer and Information Sciences and Health Sciences, Northeastern University, Boston, MA, USA
xxiv Bradley Erickson , MD, PhD Department of Radiology and Medical Informatics , Mayo Clinic , Rochester , MN , USA R. Scott Evans , BS, MS, PhD, FACMI Medical Informatics Department , LDS Hospital, Intermountain Healthcare , Salt Lake City , UT , USA Valerie Florance , PhD, FACMI Division of Extramural Programs, National Library of Medicine , National Institutes of Health, DHHS , Bethesda , MD , USA Ian T. Foster , PhD Searle Chemistry Laboratory, Computation Institute , University of Chicago and Argonne National Laboratory , Chicago , IL , USA Carol Friedman , PhD, FACMI Department of Biomedical Informatics , Columbia University , New York , NY , USA Charles P. Friedman , PhD, FACMI Schools of Information and Public Health, University of Michigan , Ann Arbor , MI , USA Mark E. Frisse , MD, MS, MBA, FACMI Department of Biomedical Informatics , Vanderbilt University Medical Center , Nashville , TN , USA Reed M. Gardner , PhD, FACMI Department of Informatics , University of Utah, Biomedical Informatics , Salt Lake City , UT , USA Kenneth W. Goodman , PhD, FACMI University of Miami Bioethics Program , Miami , FL , USA Robert A. Greenes , MD, PhD, FACMI Department of Biomedical Informatics , Arizona State University , Tempe , AZ , USA Division of Health Sciences Research , College of Medicine, Mayo Clinic , Scottsdale , AZ , USA Hayit Greenspan , PhD Department of Biomedical Engineering, Faculty of Engineering , TelAviv University , Tel Aviv , Israel W. Edward Hammond , PhD, FACMI Duke Center for Health Informatics, Duke University Medical Center , Durham , NC , USA William R. Hersh , MD FACMI, FACP Department of Medical Informatics and Clinical Epidemiology , Oregon Health and Science University , Portland , OR , USA George Hripcsak , MD, MS, FACMI Department of Biomedical Informatics , Columbia University Medical Center , New York , NY , USA Stanley M. Huff , MD, FACMI Medical Informatics , Intermountain Healthcare , Murray , UT , USA Charles Jaffe , PhD Health Level Seven International , Del Mar , CA , USA Holly Brugge Jimison , PhD, FACMI Consortium on Technology for Proactive Care, Colleges of Computer and Information Sciences and Health Sciences, Northeastern University , Boston , MA , USA Contributors
Contributors Kevin Johnson, MD, MS, FACMI Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA David R. Kaufman, PhD Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ, USA Isaac s. Kohane MD. PhD. FACMI Harvard Medical School Center for Biomedical Informatics and Childrens Hospital Informatics Program, Boston. MA usa Martin La venture, MPH, PhD, FACMI Minnesota Department of health. office of hit and e-Health. Center for health Informatics St Paul. mN. Us Kenneth D. Mandl, MD, MPH, FACMI Childrens Hospital Informatics Program, Harvard Medical School, Boston Childrens Hospital Boston. MA uSa Roger G. Mark, MD, PhD Institute of Medical Engineering and Science, Department of Electrical Engineering and Computer Science(EECS), Massachusetts Institute of Technology, Cambridge, MA, USA Clement McDonald, MD, FACMI Office of the Director, Lister Hill National Center for Biomedical Communications, National Library of Medicine. National Institutes of health. Bethesda. MD. USA Blackford Middleton, MD, MPH, MSc, FACMI Informatics Center, Vanderbilt University Medical Center, Nashville, TN, USA Randolph A Miller, MD, FACMI Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA Sean D. Mooney, PhD Buck Institute for Research on Aging, Novato. CA USA Mark A Musen, MD, PhD, FACMI Center for Biomedical Informatics Research, Stanford University School of Medicine, Stanford, CA, USA Scott P Narus, PhD Department of Medical Informatics, Intermountain Healthcare, Murray, UT, USA Thomas S Nesbitt, MD, MPH Department of Family and Community Medicine, School of Medicine, UC Davis Health System, Sacramento, Douglas K. Owens, MD, MS, VA Palo Alto Health Care System and H.J. Kaiser Center for Primary Care and Outcomes Research/Center for Health Policy, Stanford University, Stanford, CA, USA Judy Ozbolt, PhD, RN, FAAN, FACMI, FAIMBE Department of Organizational Systems and Adult Health, University of Maryland School of Nursing, Baltimore, MD, USA Vimla L Patel, PhD, DSc, FACMI Center for Cognitive Studies in Medicine and Public Health, The New York Academy of Medicine, New York, NY, USA
xxv Kevin Johnson , MD, MS, FACMI Department of Biomedical Informatics , Vanderbilt University School of Medicine , Nashville , TN , USA David R. Kaufman, PhD Department of Biomedical Informatics , Arizona State University , Scottsdale , AZ , USA Isaac S. Kohane, MD, PhD, FACMI Harvard Medical School Center for Biomedical Informatics and Children’s Hospital Informatics Program, Boston, MA, USA Martin LaVenture , MPH, PhD, FACMI Minnesota Department of Health , Offi ce of HIT and e-Health, Center for Health Informatics , St. Paul , MN , USA Kenneth D. Mandl , MD, MPH, FACMI Children’s Hospital Informatics Program , Harvard Medical School, Boston Children’s Hospital , Boston , MA , USA Roger G. Mark , MD, PhD Institute of Medical Engineering and Science , Department of Electrical Engineering and Computer Science (EECS), Massachusetts Institute of Technology , Cambridge , MA , USA Clement J. McDonald , MD, FACMI Offi ce of the Director , Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health , Bethesda , MD , USA Blackford Middleton , MD, MPH, MSc, FACMI Informatics Center , Vanderbilt University Medical Center , Nashville , TN , USA Randolph A. Miller , MD, FACMI Department of Biomedical Informatics , Vanderbilt University Medical Center , Nashville , TN , USA Sean D. Mooney , PhD Buck Institute for Research on Aging , Novato , CA , USA Mark A. Musen , MD, PhD, FACMI Center for Biomedical Informatics Research, Stanford University School of Medicine , Stanford , CA , USA Scott P. Narus , PhD Department of Medical Informatics , Intermountain Healthcare, Murray , UT , USA Thomas S. Nesbitt , MD, MPH Department of Family and Community Medicine, School of Medicine, UC Davis Health System , Sacramento , CA , USA Douglas K. Owens, MD, MS, VA Palo Alto Health Care System and H.J. Kaiser Center for Primary Care and Outcomes Research/Center for Health Policy , Stanford University, Stanford , CA , USA Judy Ozbolt , PhD, RN, FAAN, FACMI, FAIMBE Department of Organizational Systems and Adult Health , University of Maryland School of Nursing , Baltimore , MD , USA Vimla L. Patel , PhD, DSc, FACMI Center for Cognitive Studies in Medicine and Public Health , The New York Academy of Medicine , New York , NY , USA Contributors