廳遗 Epigenetics Chromatin based gene control Chaoqun Wu School of Life Sciences, Fudan University 2005-10-29 Chaoqun Wu, Fudan University
2005-10-29 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 1 Epigenetics — Chromatin based gene control Chaoqun Wu School of Life Sciences, Fudan University
Part v Chromatin remodeling 2005-10-29 Chaoqun Wu, Fudan University
2005-10-29 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 2 Part V. Chromatin remodeling
“香 一 Nucleosome 50 nm linker DNA core histones of nucleosome ○ DISSOCIATION TH A HIGH beads-on-a-string CONCENTRATION form of chromatin OF SALT includes 200 NUCLEASE DIGESTS nucleotide pairs LINKER DNA f DNA 8C2 ctameric histone core dNa double helix ISSOCIATION cle core particle H2A H2B H3 H4 Essential Cell Biology by alberts et al. 1997 2005-10-29 Chaoqun Wu, Fudan University
2005-10-29 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 3 Nucleosome Essential Cell Biology by Alberts et al. 1997
What is Chromatin remodeling Chromatin remodeling(染色质重构)isan important epigenetic mechanism Chemical modification of the protruding histone tails- by the addition of acetyl methyl or phosphate groups-can alter chromatin structure, which in turn influences the activity of adjacent genes 2005-10-29 Chaoqun Wu, Fudan University
2005-10-29 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 4 What is Chromatin remodeling Chromatin remodeling(染色质重构)is an important epigenetic mechanism. Chemical modification of the protruding histone tails — by the addition of acetyl, methyl or phosphate groups — can alter chromatin structure, which in turn influences the activity of adjacent genes
The remodeling of chromatin allows transcription factors to bind their cognate DNA Sites. Associated proteins with structural, modifying and/or transcriptional activities propagate and/or stabilize the actively transcribing chromatin structure leading to expression of the gene. The temporal order of interactions between cis and trans elements can vary 2005-10-29 Chaoqun Wu, Fudan University
2005-10-29 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 5 The remodeling of chromatin allows transcription factors to bind their cognate DNA sites. Associated proteins with structural, modifying and/or transcriptional activities propagate and/or stabilize the actively transcribing chromatin structure, leading to expression of the gene. The temporal order of interactions between cis and trans elements can vary