药剂学 Pharmaceutics 第五章 固体制剂-2 (胶囊剂、滴丸和膜剂) 长沙医学院药学系药剂教研室 黄明秋
第 五 章 固体制剂-2 （胶囊剂、滴丸和膜剂） 药 剂 学 Pharmaceutics 长沙医学院药学系药剂教研室 黄明秋
第一节胶囊剂 、概述 胶囊剂( capsules)——药物装于空心硬质胶 囊中或密封于弹性软质胶囊中而制成的固体 制剂
第一节 胶囊剂 胶囊剂(capsules)——药物装于空心硬质胶 囊中或密封于弹性软质胶囊中而制成的固体 制剂. 一、概述
The capsules are made in two parts by dipping metal rods in molten starch or cellulose solution. The capsules are supplied as closed units to the pharmaceutical manufacturer Before use, the two halves are separated, the capsule is filled with powder (either by placing a compressed slug of powder into one half of the capsule, or by filling one half of the capsule with loose powder)and the other half of the capsule is pressed on. James Murdock patented the two-part telescoping gelatin capsule in London in 1847
The capsules are made in two parts by dipping metal rods in molten starch or cellulose solution. The capsules are supplied as closed units to the pharmaceutical manufacturer. Before use, the two halves are separated, the capsule is filled with powder (either by placing a compressed slug of powder into one half of the capsule, or by filling one half of the capsule with loose powder) and the other half of the capsule is pressed on. James Murdock patented the two-part telescoping gelatin capsule in London in 1847
>In 1834, Mothes and dublanc were granted a patent for a method to produce a single-piece gelatin capsule that was sealed with a drop of gelatin solution. They used individual iron moulds for their process, filling the capsules individually with a medicine dropper. >All modern soft-gel encapsulation uses variations of a process developed by r. p Scherer in 1933. His innovation was to use a rotary die to produce the capsules, with the filling taking place by blow molding. This method reduced wastage, and was the first process to yield capsules with highly repeatable dosage
➢In 1834, Mothes and Dublanc were granted a patent for a method to produce a single-piece gelatin capsule that was sealed with a drop of gelatin solution. They used individual iron moulds for their process, filling the capsules individually with a medicine dropper. ➢All modern soft-gel encapsulation uses variations of a process developed by R.P. Scherer in 1933. His innovation was to use a rotary die to produce the capsules, with the filling taking place by blow molding. This method reduced wastage, and was the first process to yield capsules with highly repeatable dosage
胶囊剂的特点: (1)能掩盖药物不良嗅味、提高药物稳定性; (2)药物在体内起效快; (3)液体药物的固体剂型化; (4)可延缓药物释放和定位释药
（1）能掩盖药物不良嗅味、提高药物稳定性； （2）药物在体内起效快； （3）液体药物的固体剂型化； （4）可延缓药物释放和定位释药. 胶囊剂的特点：