GIST Localisation(GSRCB*) n=1295 esophagus 1,1% stomach 59,1% small bowel 32. 2% large bowel 5, 2% (pref rectum) E-GIST 2,4% E-GIST Extra-gastrointestinal GIST GSRCB: GIST and Sarcoma Registry Cologn e/Bonn) Courtesy of Dr E. Wardelmann
Morphological Subtypes (GSRCB*) 100% 129 90% 80% epithelioid 227 70% 60% mixed 50% (intermediate 40% or biphasic) 30% 644 20% 10% spindle cell 0% 2010 spindle amixed epithelioid n=1614 Corless cl et al. Annu Rev Patho. 2008: 3: 557-586 Fletcher cD et al. Hum Pathol 2002: 33: 459-456 Wardelmann E et al. J Mol Diagn. 2004: 6: 197-204 GSRCB: GIST and Sarcoma Registry Cologn e/Bonn
GIST Diagnosis Immunohistochemistry 70-80% 95% CD3 KIT 98% 80% DOG1 PDGFRa monoclonal, clone SP31, 1: 100, MW, pH 8, Medac (Spring Bioscience) Courtesy of Eva Wardelmann
a Differential Diagnosis Cellular schwannoma 100 Courtesy of Dr E. wardelmann, University of Bonn Medical centel