kb i Consensus region ACTTTTATTTAAGTATTGTTTGTGCCTTTTGAAAAGCAAGCATAAAAGATCTAAACATAAAATCTGTAAAAT TGAAAATAAATTCATAACAAACACGGAAAACTTTTCGTTCGTATTTTCTAGATTTGTATTT TAGACATTTTA
Problems at the 5 -end of dna RNA primer 535~3 L3 RNA primer Synthesis of new DNA strands by addition to the 3 end of the RNA primers DNA polymerase-DNA polymerase 3 3 Rem。val。 f RNa primers by rib。 nucleases 3 Gap Gap 5 3 Newly synthesized strands are shorter by the length of the rna primer
Telomeres and telomerase Binding of telomerase Telomerase DNA 53 . CGGTTAGGGTTACGGTTACGG Protein AaTc 5 AATcc RNA 5 Elongation .GCGTTAGGGTTACGCTTACGGTT .CCcAATO AATCCCAATI Translocation . GGGTTAGGGTTACGGTTAGGGTTAI . CCCAATaCCI NewTTAGG G Elongation segment added GGGTTAGGGTTASGGTTAGGGTTAGGGTTA .CCCAAT CAATCCCAA
Telomere structure 5 TTAGGG 3 G-G hydrogen Hairpin bonds loop 3 end free to act as primer
Telomere's functions 1. keep chromosomes from shortening 2. prevent chromosome fusion 3. ageing? 4 cancer?
Telomere’s functions • 1. keep chromosomes from shortening • 2. prevent chromosome fusion • 3. ageing? • 4. cancer?