Recommended Text PRINCIPLES Of 中文压 CLINICAL PHARMACOLOGY SECOND EDITIOIN Clinical Pharmacology 味药理学 Principles of 床中心典课程讲 理 Arthur J.Atkinson,r.Darrell R.Abernethy. Charles E.Daniels,Robert Dedrick and Saoford P.Markey pA Atkinson AJ and Wei Wei,2009,Beijing Clinical Pharmacology:Current Topics and Case Studies.Springer Vienna,2010. (Prof.Dr.Markus Miiller. Methods in Clinical Pharmacology.Springer Berlin Heidelberg,2011. Hans Gerhard Vogel,et al
Recommended Text Atkinson AJ and Wei Wei, 2009, Beijing Clinical Pharmacology: Current Topics and Case Studies. Springer Vienna, 2010. (Prof. Dr. Markus Müller. ) Methods in Clinical Pharmacology. Springer Berlin Heidelberg, 2011. ( Hans Gerhard Vogel, et al. )
Today,Introduction to Clinical Pharmacology (Unit 1) Important history events of modern pharmacology Development of clinical pharmacology The relationship between health,disease and drug Clinical Pharmacokinetics Clinical Pharmacodynamics ■ Clinical evaluation of new drugs Hot spots in research of clinical pharmacology
Today, Introduction to Clinical Pharmacology (Unit 1) Important history events of modern pharmacology Development of clinical pharmacology The relationship between health, disease and drug Clinical Pharmacokinetics Clinical Pharmacodynamics Clinical evaluation of new drugs Hot spots in research of clinical pharmacology
Important history events of modern pharmacology 1806:Friedrich Wilhelm Serturner, a German pharmacologist, separated morphine from opium poppy(罂粟)， which has a analgesic action with dogs. (morphine,spoonerism of Greece Morpheus.) 1819:Francois Magedie (French physiologist found that action site of strychnine(士的宁)from Strychnos plants(马钱子)was at spinal cord with frogs. the first symptoms to appear are generalized muscle spasms,and opisthotonus(角弓反张)
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1878:John Newport Langley from Cambridge University raise the concept of receptor depending on different actions of atropine and pilocarpine (毛果芸香碱)for salivary secretion of cats (acetylcholine receptors) 心a“y pilocarpine stimulate salivary secretion Parotid gland M-R Submandibular gland atropine Sublingual gland reduce salivary secretion Salivary Glands Muscarinic Receptor
1878: John Newport Langley from Cambridge University raise the concept of receptor depending on different actions of atropine and pilocarpine (毛果芸香碱) for salivary secretion of cats. (acetylcholine receptors) M-R pilocarpine atropine + - stimulate salivary secretion reduce salivary secretion Muscarinic Receptor
1897:Felix Hoffman,German Bayer corporation, synthesized acetylsalicylic acid(aspirin). 2-acetoxybenzoic acid Felix Hoffman In 1971,Sir John Vane,British pharmacologist, discovered that aspirin and similar drugs produced their effects because they inhibited the biosynthesis of prostaglandins. In 1982,Sir John Vane obtained Nobel prize in physiology or medicine. John Vane Wei W.Memorial for Sir John Vane-Nobel prize in physiology or medicine. Chinese Pharmacol Bulletin,2005;21(2):II
1897：Felix Hoffman, German Bayer corporation, synthesized acetylsalicylic acid (aspirin). Felix Hoffman In 1971, Sir John Vane, British pharmacologist, discovered that aspirin and similar drugs produced their effects because they inhibited the biosynthesis of prostaglandins. In 1982, Sir John Vane obtained Nobel prize in physiology or medicine. John Vane Wei W. Memorial for Sir John Vane－Nobel prize in physiology or medicine. Chinese Pharmacol Bulletin, 2005;21(2)：II