2. Heymann gn of rat Antigen---proximal tubular brush border( megalin) resemble human membranous gn IF: Granular patte EM: Subepithelial electron dense deposit Megalin Associates with Clathrin in the Proximal Tubule Other causes: DNA, products of bacteria virus protein
2. Heymann GN of rat Antigen--- proximal tubular brush border ( megalin) resemble human membranous GN IF: Granular pattern EM: Subepithelial electron dense deposit Other causes: DNA， products of bacteria ， virus protein
Basic pathological changes Extent of glomerular lesion Diffuse -almost every glomeruli involved Focal- partial (50%)glomeruli involved Global -generalized capillary loop Segmental- partial capillary loop
三. Basic pathological changes • Extent of glomerular lesion Diffuse – almost every glomeruli involved Focal – partial (<50%) glomeruli involved Global – generalized capillary loop Segmental – partial capillary loop
focal segmental lesion 好 e 军
focal segmental lesion
Cells proliferation O Hypercellularity--- increase intrinsic glomerular cells proliferation of endothelial cells and mesangial cells in mesangial regions with increasing metrix proliferation of epithelial cells-forming crescents o infiltrated inflammatory cells
1．Cells proliferation ● Hypercellularity--- increase intrinsic glomerular cells proliferation of endothelial cells and mesangial cells — in mesangial regions with increasing metrix proliferation of epithelial cells — forming crescents ● infiltrated inflammatory cells
2.基膜增厚 Thickening of GBM ●免疫复合物沉积—上皮下、内皮下沉积伴基膜新生 Immune complexes deposites under epithelial or endothelial cell with thickening or duplication of GBM ●系膜细胞或基质插入一系膜区扩大所致 Interposition of mesangial cell and matrix Outcomes The destroy of gbm mechanical barrier and negatively charged barrier Increase the GBM pemeability and proteinuria
2. 基膜增厚 Thickening of GBM ● 免疫复合物沉积—上皮下、内皮下沉积伴基膜新生 Immune complexes deposites under epithelial or endothelial cell with thickening or duplication of GBM ● 系膜细胞或基质插入—系膜区扩大所致 Interposition of mesangial cell and matrix Outcomes: The destroy of GBM mechanicalbarrier and negatively charged barrier Increase the GBM pemeability and proteinuria