Glomerular filtrating membrane Fenestrated endothelium---70- 100nm Glomerular basement membrane (GBM) a meshwork of fine fibrils( Col-IV,laminin) embedded in an amorphous matrix(FN Epithelium--- podocyte epithelial slit 20-50 nm thin slit diaphragm 4 14 nm LD Capillarary lumen
Glomerular filtrating membrane • Fenestrated endothelium --- 70 ~ 100nm • Glomerular basement membrane (GBM) --- a meshwork of fine fibrils (Col- IV ,laminin) embedded in an amorphous matrix ( FN ) • Epithelium --- podocyte epithelial slit 20 ~ 50 nm, thin slit diaphragm 4 ~ 14 nm Capillarary lumen
肾球囊 Bowman's capsule Parietal epithelial cells-flat cells
● 肾球囊 Parietal epithelial cells — flat cells Bowman’s capsule
Etiology and pathogenesis of Glomerulonephritis Primary GN-- limited in kidney along Secondary gn-- associated with systemic diseases Primary GN: A group of hypersensitivity diseases Glomerular injury coused by immune complexes Two forms of abtibody associalted injury Circulating immune complex nephritis Immune complex nephritis in situ
二. Etiology and Pathogenesis of Glomerulonephritis Primary GN --- limited in kidney along Secondary GN --- associated with systemic diseases •Circulating immune complex nephritis •Immune complex nephritis in situ Primary GN: A group of hypersensitivity diseases Glomerular injury coused by immune complexes Two forms of abtibody associalted injury
Circulating immune complex nephritis exogenous: bacteria, virus, parasite foreign serum, drug, toxin endogenous: macroglobulin, thyroglobulin CEA
• Circulating immune complex nephritis exogenous: bacteria， virus， parasite foreign serum，drug，toxin endogenous: macroglobulin， thyroglobulin， CEA
Ag-Ab Immune Complex complex Glomerulonephritis Antigen Antibody