4.奇数碳原子脂肪酸的氧化 首先经过数次β氧化,最后剩下 个丙酰CoA oPropionyI-CoA( three amino acids) is converted to succinyl-COA
4. 奇数碳原子脂肪酸的氧化 ◆首先经过数次-氧化，最后剩下一 个丙酰CoA. ◆Propionyl-CoA ( three amino acids) is converted to succinyl-CoA
Carb oxylase( Biotin) Racemase Mutase 000 H C00 H C00 HCO3 H-C-CHe H-C-CHBH-c-c-H H-C-C一H C一SA C-S-COA ATP ADP HC--00Ac0As一CH Convertion of Propionyl-CoA to succinyl-CoA The carboxyl that is in ester linkage to the thiol of coenzyme A is shifted from one carbon atom to another, with opposite shift of a hydrogen atom
Convertion of Propionyl-CoA to succinyl-CoA The carboxyl that is in ester linkage to the thiol of coenzyme A is shifted from one carbon atom to another, with opposite shift of a hydrogen atom
S-CoA S-CoA 5.酮体的生成与 2 Acetyl-CoA 利用 HMG-CoAr Acetyl-CoA +Hgo (1 Excess acetyl CoA-SH Coa in liver can be -CHe CoA B-Hydroxy-Bl-methylghutaryl-CoA exported as ketone (HMG-COA) bodies Acetyl-CoA NADH b-iHhydroxybutyrate +H NAD CH,-C-CH3 C-CH -CH-CHg
5. 酮体的生成与 利用 （1） Excess acetylCoA in liver can be exported as ketone bodies