HLA分型技术
1 HLA分型技术
Major Histocompatibility Complex(MHC)WhatisMHC?_HLA- H-2Minorrhistocompatibility antigens
2 Major Histocompatibility Complex (MHC) ➢ What is MHC? – HLA – H-2 – Minor histocompatibility antigens
Significance of the MHCroleinimmuneresponse> role in organ transplantation> role in predisposition to disease
3 Significance of the MHC ➢ role in immune response ➢ role in organ transplantation ➢ role in predisposition to disease
Genetic barriers to transplantationautologous:inthe sameisograftindividual (autograft)商isologous:betweengeneticallyIdenticalallograftindividuals (isograft),i.e.,autograftidenticaltwins(inbred惠animals)商homologous:betweenindividuals of the samexenograftspecies (allograft)heterologous:betweenindividualsdifferentspecies(xenograft)
5 Genetic barriers to transplantation • autologous: in the same individual (autograft) • isologous: between genetically Identical individuals (isograft), i.e., identical twins (inbred animals) • homologous: between individuals of the same species (allograft) • heterologous: between individuals different species (xenograft)
Principles of transplantationDonorRecipientGraftHostAHostAacceptedGraftHostBHostArejectedGraftHostBHostAxBacceptedGraftHostAxBHostBrejected
6 Principles of transplantation