Minor histocompatibility antigensand graft survivalminor histocompatibility antigens alsocause rejectionThe rejection time is variable butlongerthanthatformajorhistocompatibilityantigenThey have additive effects
7 Minor histocompatibility antigens and graft survival ➢ minor histocompatibility antigens also cause rejection ➢ The rejection time is variable but longer than that for major histocompatibility antigen ➢ They have additive effects
Graft versus host (GVH)diseaseAnimal X-irradiatedDonorAnimalApriortotransplant(immunocompromized)ImmunocompetentcellsRecipientAxBRecipientCDivision of donorcellsRecipientsanimals die
8 Graft versus host (GVH) disease
GVH disease in humans
9 GVH disease in humans
The human MHC genesclassIlclassDQDRDP4BADRDPDQ10
10 The human MHC genes class II class I DP DQ DR B C A B C A DP DQ DR 2 2 1 1 2 2 3 1 1 1 2 3 9
The mouse MHC genesclass IIclass IIIclass Iclass I(C4, factor-B,TNF, etc.)KD00.00XAE
11 The mouse MHC genes I K D A E class I class II class III class I (C4, factor-B,TNF, etc.)