Fish trap model NUCLEOPLASM Inner membrane Nuclear of nuclear envelope pore complex ←-120nm "Basket" Anchor Cytoplasmic of fibers filaments Nuclear protein Spoke lamina Ring complex subunit Cytoplasmic ring Spoke Outer membrane Lumenal of nuclear Nucleoplasmic ring Transporter envelope ring Fiber Nuclear Central basket channel Endoplasmic reticulum Ribosomes CYTOSOL
Fish trap model
Structure of the nuclear pore complex from D.discoideum盘基网柄菌 A CR INM ONM INM NPC NR 909 E CR ONM SR NR
Structure of the nuclear pore complex from D. discoideum 盘基网柄菌
(二)组成成分 Cytoplasmic FG 核孔蛋白（nucleoporin,.Nup) Nups and filaments Spoke Yeast: Vertebrate: Cytoplasmic filament NUP358 Central tube Cytoplasm Nup159 NUP214 Nup42 NLPT ONM Transmembrane ring Nups Nuclear Yeast: Vertebrate envelope INM Pom152 GP210 Pom34 Ndcl NDCI Outer ring Nups Nucleoplasm POM121 Yeast: Vertebrate: Basket Nup133 NUP133 Central FG Nups Nup120 NUP160 Yeast: Vertebrate: Nuclear FG Nups and Inner ring Nups Nup145C NUP96 Nup145N NUP98 the basket Yeast: Vertebrate Nup85 NUP75 Nupl16 Yeast: Vertebrate: Nup192 NUP205 Nup84 NUP107 Nup100 Nup60 NUP153 Nup188 NUP188 Sehl SEHI Nspl NUP62 Nupl Linker Nups Nupl70 NUP155 Secl3 SEC13 Nup57 NUP54 Nup2 Yeast: Vertebrate: Nup157 NUP43 Nup49 NUP58 and Mlpl TPR Nic96 NUP93 Nup53 NUP35 NUP37 NUP45 MIp2 Nup82 NUP88 Nup59 Aladin Nature Reviews Molecular Cell Biology 11,490-501 (July 2010)|doi:10.1038/nmm2928 Core scaffold Nups
（二）组成成分 Nature Reviews Molecular Cell Biology 11, 490-501 (July 2010) | doi:10.1038/nrm2928 核孔蛋白 （nucleoporin，Nup）
核孔蛋白(nucleoporin,Nup) Gp210:结构性跨膜蛋白 —120nm Nup358/RanBP2 -介导NPC与核被膜连接 CAN/Nup214 一在内、外核膜融合形成核孔 Nup84? 中起重要作用 CYTOPLASM 一在核质交换中起作用 gp210 P0M121 ~200 nm ·p62:功能性Nup NUCLEUS -疏水性N端区：具有FXFG Nup93? 重复序列 Nup96? Nup98? Nup107? p62 Nup153 一C端区：具有疏水性的7肽 p205? p58/54/45 Nup155? 重复序列 Tpr http://npd.hgu.mrc.ac.uk/user/?page=nuc_pore
核孔蛋白（nucleoporin，Nup） • Gp210：结构性跨膜蛋白 – 介导NPC与核被膜连接 – 在内、外核膜融合形成核孔 中起重要作用 – 在核质交换中起作用 • p62：功能性Nup – 疏水性N 端区： 具有FXFG 重复序列 – C 端区：具有疏水性的7肽 重复序列 http://npd.hgu.mrc.ac.uk/user/?page=nuc_pore
(三)功能 ·双功能、双向性的亲水 Energy-dependent Passive diffusion transport 性核质交换通道 Proteins Small molecules Nucleus RNAS
（三）功能 • 双功能、双向性的亲水 性核质交换通道