第8章细胞信号转导 EXTRACELLULAR CYTOPLASM FLUID ①Reception ②Transduction ③Response Receptor Activation ●→ of cellular responses Signal-transduction pathway Signal molecule Plasma membrane
第8章 细胞信号转导
本章主要内容 ·细胞信号转导概述 ·细胞内受体介导的信号传递 ·细胞表面受体介导的信号传递 一G蛋白偶联受体介导的信号传递 一酶联受体介导的信号传递 一其它细胞表面受体介导的信号传递 ·细胞信号转导的整合与控制
本章主要内容 • 细胞信号转导概述 • 细胞内受体介导的信号传递 • 细胞表面受体介导的信号传递 – G蛋白偶联受体介导的信号传递 – 酶联受体介导的信号传递 – 其它细胞表面受体介导的信号传递 • 细胞信号转导的整合与控制
第一节细胞信号转导概述 ,细胞通讯cell communication步骤与功能 2 SURVIVE Signaling cell 03 8 0000o 8 GROW+DIVIDE ④ Cell surface receptor DIFFERENTIATE Responding cell Modification of Modification of cellular metabolism, gene expression, function,movement development DIE◆ apoptotic cell Figure 15-8 Molecular Biology of the Cell(Garland Science 2008)
第一节 细胞信号转导概述 • 细胞通讯 cell communication 步骤与功能 Figure 15-8 Molecular Biology of the Cell (© Garland Science 2008)
信号转导Signal transduction A signaling molecule activates a specific receptor on the cell membrane. A second messenger transmits the signal into the cell,eliciting a physiological response. electrical signal extracellular signal IN molecule 88 AIN sound OUT intracellular signaling molecule B OUT 2 ⑧③ Conversion of information from one form into another
信号转导 Signal transduction • A signaling molecule activates a specific receptor on the cell membrane. • A second messenger transmits the signal into the cell, eliciting a physiological response. Conversion of information from one form into another
细胞通讯 化学信号通讯 ·接触依赖性通讯(contact-.dependent signaling） ·间隙连接 (gapjunction)胞间连丝(plasmodesma) CONTACT-DEPENDENT Chemical nessenge signaling cell target cell 80. Receptor lons and Secretory Target cell cell membrane- Cell 2 bound signal (b)Communication via chemical messengers molecule (a)Direct communication through gap junctions
一、细胞通讯 • 化学信号通讯 • 接触依赖性通讯（contact-dependent signaling） • 间隙连接（gap junction）胞间连丝（plasmodesma）