(一) 核膜结构 NUCLEOPLASM Inner membrane Nuclear of nuclear envelope pore complex ←-120nm “Basket' of fibers Anchor Cytoplasm Nuclear protein Peripheral ER lamina Ring subunit Spoke Outer ONM membrane Transporter of nuclear INM envelope Fiber Nuclear lamina Endoplasmic reticulum Nucleoplasm Ribosomes CYTOSOL (b)Location of nuclear pores in nuclear membrane 2012 Pearson Education,Inc
（一）核膜结构
(二) 核膜的崩解与组装 Prophase -Chromosome -Nuclear Lamina -Mitotic spindle O LAP2 Emerin Interphase Metaphase ●SUN1 Centrosome Nuclear pore complex Telophase Anaphase
（二）核膜的崩解与组装
Breakdown and reformation of nuclear envelope during mitosis nuclear pore lamins DNA complex. nuclear inner nuclear membrane nuclear envelope outer nuclear membrane PHOSPHORYLATION pore FUSION OF ENVELOPED OF LAMINS complex phosphorylated proteins CHROMOSOMES lamins INTERPHASE NUCLEUS chromatid nuclear chromosome envelope LATE fragment TELOPHASE PROPHASE FUSION OF NUCLEAR DEPHOSPHORYLATION ENVELOPE FRAGMENTS OF LAMINS EARLY TELOPHASE
Breakdown and reformation of nuclear envelope during mitosis
二、核孔复合体 Cell Science The Nuclear Pore Complex S.Bagley,M.W.Goldberg.J.M.Cronshaw,S.A.Rutherford and T.D.Allen
二、核孔复合体
(一)结构模型 “fish-trap”model ·胞质环(cytoplasmic ring) ·核质环(nuclear ring) ·辐（spoke):柱状亚单位；腔内亚单位；环带亚单位 ·中央栓(central plug),中央颗粒(central granule) 纤维 中央栓 胞质环 外核膜 腔内亚单位 核被膜 内核膜 柱状亚单位 核篮 核质环 核纤层
（一）结构模型—— “fish-trap”model • 胞质环（cytoplasmic ring） • 核质环（nuclear ring） • 辐（spoke）：柱状亚单位；腔内亚单位；环带亚单位 • 中央栓（central plug），中央颗粒 （central granule）