免疫反应基因 Immune response genes Barui benacerraf 不同种系小鼠对一些抗原产生不同的抗体 反应( Responder vs.non- responder strains 免疫反应基因r( mmune response) genes定 位于MHC基因区域
免疫反应基因 Immune response genes • Baruj Benacerraf • 不同种系小鼠对一些抗原产生不同的抗体 反应 (Responder vs. non-responder strains) • 免疫反应基因Ir(Immune response ) genes 定 位于MHC基因区域
1980 Nobel prize Baruj Benacerraf, Jean Dausset and George D Snell
1980 Nobel Prize Baruj Benacerraf, Jean Dausset and George D. Snell
Infect strain A mouse with Strain A Strain B lymphocytic choriomeningitis virus(LCMv) Self Target Target MHC限制性 infect target cells with lcMv 7 da LCMV CTLs Cytotoxicity assay and measure lysis of target cells CTL Target cell Specific lysis CMV pepti Self peptid Strain A CTL recognizes LCMV E viral peptide infected +self MHC Yes Failure to Strain A ize self uninfected peptide self MHC No Failure to Strain B recognize LCMV viral peptide infected allogeneic MHC No
MHC限制性
MHC限制性 MHC restriction T cell T cell T C TCR TCR TCR HLA-A HLA-B HLA-A 0201 5201 0201 antigen-presenting cell antigen- presenting cell antigen- presenting cel Recognition No recognition No recognition
MHC 限制性
1996 Nobel prize Doherty and Zinkernagel
Doherty and Zinkernagel 1996 Nobel Prize