Immunohistochemistry:IgG(+)
Immunohistochemistry:IgG(+)
() Clinical courseAdult→non-selective proteinuriaChronic progression→because ofincreasing sclerosis of glomeruli10% go into failure or die within10years25% develop renal insufficiency
(6) Clinical course ▪ Adult→non-selective proteinuria ▪ Chronic progression→because of increasing sclerosis of glomeruli ▪ 10% go into failure or die within 10 years ▪ 25% develop renal insufficiency
GN2. Minimal change(LipiodI neprosis)The most frequent cause of NSin childrenThe peak incidence: between2 to 8 years of age
2. Minimal change GN ( Lipiod neprosis ) The most frequent cause of NS in children The peak incidence: between 2 to 8 years of age
(1) FeaturesDiffuse loss of foot processesofpodocytesGlomerulusappears normallyLMby
(1) Features ▪ Diffuse loss of foot processes of podocytes ▪ Glomerulus appears normally by LM
(2) Pathological changes1)Gross:Enlarged and pale2LM:- Appear normally-→glomeruli- Renal tubule: lipid droplets→proximal tubules
(2) Pathological changes ① Gross: Enlarged and pale ② LM: ▪ Appear normally→glomeruli ▪ Renal tubule: lipid droplets →proximal tubules