Section I Rheumatism
n General Rheumatism or rheumatic disorder is a non-specific term for medical problems affecting the joints and connective tissue Types: Ankylosing spondylitis, Osteoarthritis Systemic lupus erythematosus Rheumatic fever Rheumatic heart disease etc
In General ◼ Rheumatism or rheumatic disorder is a non-specific term for medical problems affecting the joints and connective tissue. ◼ Types: Ankylosing spondylitis, Osteoarthritis Systemic lupus erythematosus Rheumatic fever Rheumatic heart disease etc
Etiology Occurs after an episode of group A streptococcal (Streptococcus pyogenes bacteria) pharyngitis Incidence: peak ages are between 5 and 15 yrs Streptococcus pyogenes a bacteria. A pus specimen viewed using Pappenheim's stain
◼ Occurs after an episode of group A streptococcal (Streptococcus pyogenes bacteria) pharyngitis ◼ Incidence: peak ages are between 5 and 15 yrs Etiology Streptococcus pyogenes bacteria. A pus specimen, viewed using Pappenheim's stain
Pathogenesis Immunologically mediated, multisystem disease that follows an episode of group A streptococcal pharyngitis after an interval of a few weeks Type ll hypersensitivity reaction (molecular mimicry)
Pathogenesis ◼ Immunologically mediated, multisystem disease that follows an episode of group A streptococcal pharyngitis after an interval of a few weeks ◼ Type II hypersensitivity reaction (molecular mimicry)
Pathogenesis strep infection athogenesis and Pathophysiology rheumatic fever mmune response to strep antigen L ventricular hypertroph impaired systolic ejec on cell surface o-wtomurmurton rheumatic heart disea atory response aortic crosssection ast activity aortic valve stenosis in heart/skin/connective tissue buildup of fibrotic connective tissue Sydenham,s chorea hanges in vascular permeability fusion of commissures joint tissue high macrophage and PMN activity (Aschoff body ter S2 truction o subcutaneous CT」 mitral cross-section acute swelling L atrial enlargemet impaired L ventricular fil diastolic mu decreased ventricular filling capacity ced exe
Pathogenesis