Amphidinolides B and C 含有氧环的大环 OH OH 小林淳 OH HO "OH OH ōH 日本北海道大学的小林淳一研究小组从Amphidinium属不同 的菌株培养液中分离得到45个从12元环到26元环不等的大环内酯 (amphidinolides)),很多具有很强的细胞毒性，对L1210和KB细胞 酯 的1C5o最低分别可达到0.14ng/mL和0.06ng/mL。如 amphidinolides B,C
Amphidinolides B and C O O O HO OH OH OH O O OH O OH OH O O O H O H OH H H 日本北海道大学的小林淳一研究小组从Amphidinium属不同 的菌株培养液中分离得到45个从12元环到26元环不等的大环内酯 (amphidinolides), 很多具有很强的细胞毒性，对L1210和KB细胞 的 I C 5 0 最 低 分 别 可 达 到 0 . 1 4 n g / m L 和 0 . 0 6 n g / m L 。 如 amphidinolides B, C 小林淳一
Polycavernoside A:a novel glycosidic macrolide HO 0 OMe OMe Polycavernosa tsudai Yotsu Yasumoto Polycavernoside A 1993 山下ま夕 A Lethal Toxin of the Red Alga 2002-2003年在菲律宾发生3起食用海草中毒事件，36人中毒，8人死亡。 Polycavernoside A:a novel glycosidic macrolide from the red alga Polycavernosa tsudai(Gracilaria edulis采样第2次中毒)by山下ま夕
Polycavernoside A: a novel glycosidic macrolide Polycavernoside A 1993 A Lethal Toxin of the Red Alga 2002-2003年在菲律宾发生3起食用海草中毒事件， 36人中毒，8人死亡。 Polycavernoside A: a novel glycosidic macrolide from the red alga Polycavernosa tsudai (Gracilaria edulis 采样第2次中毒) by 山下 まり Yotsu Yasumoto 山下 まり Polycavernosa tsudai
Lasonolide a Me Me Lasonolide A OH sponge Forcepia sp Isolated in 1994 Mexico deep-sea habitats Structure 2002,synthesized 2007 Lasonolide A (LSA)is a natural product with high and selective cytotoxicity cancer cells,including leukemia,melanomas )and glioblastomas(黑瘤和胶质细胞瘤).They kill cancer cells in a different way than most other cancer drugs. JAm Chem Soc 1994;116:6015-6
Lasonolide A Lasonolide A (LSA) is a natural product with high and selective cytotoxicity cancer cells, including leukemia, melanomas (黑瘤)and glioblastomas (黑瘤和胶质细胞瘤). They kill cancer cells in a different way than most other cancer drugs. Isolated in 1994 Structure 2002, synthesized 2007 sponge Forcepia sp Mexico deep-sea habitats J Am Chem Soc 1994; 116: 6015 -6
四、多聚内酯类 特点：两个或两个以上的酯键Polyesters 例如： OH OH OH HO OH OH OH OH HO ● 9。 3 海洋微生物Hyp0 xylon oceanicum(LL-15G256)分得的15G256a-1(), 15G256b(2)和15G256w(3)都具有一定的抗真菌活性
v特点：两个或两个以上的酯键 Polyesters v例如： O O O O O O O O O O OH OH HO OH OH O O O O O O O O OH HO O O OH OH O O O O O O O OH HO OH OH HO OH O O O O 1 O 2 3 1 5 7 21 23 27 31 1 海洋微生物Hypoxylon oceanicum (LL-15G256)分得的15G256a-1 (1), 15G256b (2) 和15G256w (3)都具有一定的抗真菌活性
多聚内酯类 OMe HO R HO MeOr HO Prof.Yoel Kashman OH OH OMe Tel Aviv University 特拉维夫大学 OH MeOi 44 membered ring with 30 Chiral C Theonella swinhoei Sw nholide A R =CH3 K.C.Nicolaou Total Syn Sw nholide B R =H Swinholides A isolated from the Red Sea sponge Theonella swinhoei in 1985. Both A and B show potent in vitro cytotoxic activity against murine leukemia L1210 and KB human epidermoid carcinoma cell lines
Swinholides A isolated from the Red Sea sponge Theonella swinhoei in 1985. Both A and B show potent in vitro cytotoxic activity against murine leukemia L1210 and KB human epidermoid carcinoma cell lines. . O HO R O O OH OH MeO O OMe HO HO OH O O O OMe HO MeO O OH S w inholide A R = C H 3 S w inholide B R = H Theonella swinhoei Prof. Yoel Kashman Tel Aviv University 特拉维夫大学 44 membered ring with 30 Chiral C K. C. Nicolaou Total Syn