Charles Best and Edward Clark Noble 88 Best friends and Teammates Best friends and Teammates Noble later played a small but critical role in the most important Canadian contribution to cancer chemotherapy research:the discovery of vinca alkaloids by his brother Robert Laing Noble.Although one might expect that a physician involved in 2 of Canada's most important medical discoveries during the 20th century must be famous,such was not Clark Noble's fate
How Do Vinblastine and Vincristine Work? Alpha tubulin Vinca alkaloids Beta tubulin Taxanes prevent prevent microtubule microtubule assembly. disassembly. One of the most important Canadian contributions to cancer research during the 20th century.The National Cancer Institute of Canada named its most prestigious award for excellence in cancer research the Robert L.Noble Prize in honour of this discovery
长春花属生物碱衍生的五个著名抗癌药物 红色区城 无系统性研究 OMe 甲就恭取代 (长表新) Me 16 HO H 缩碳入元环 (长春瑞) Me MeO2C AcO" OH 酰胺取代甲酯、 二氟取代， 无乙酰基 (+)-Vinblastine 无羟基 (长森地判 (长衣花碱) (长泰氧分 上世纪60年代，从夹竹桃科植物长春花中分离出来的长春花碱(vinblastine)和 长春新碱(vincristine),很快便成了礼来(Eli Lilly)公司开发上市的两个著名抗癌 药物—长春花碱主要用于治疗膀胱癌和乳腺癌，长春新碱主要用于治疗急性白 血病和淋巴癌
从Khellin凯林到硝苯地平 Khellin凯林1879年 Nifedipine硝苯地平 钙通道阻滞剂一高血 压、心绞痛、冠心病 拜耳公司F.Bossert 阿密芹Ammi visnaga 合成了2000个衍生物 1961合成胺碘酮amiodarone 钾通道阻滞剂用于心律失常 在埃及khella果实中含凯林(Khellin),用于治疗冠状动脉性疾病，如 狭心症、冠状血栓症等。欧洲民间用本植物医治尿泌系统疾患和通经
“疾病之王”糖尿病 Sir Harold Percival Himsworth 减少吃 油、糖、盐类 (1936年1型和2型糖尿病的区别 Elizabeth Hughes 吃适量 奶品类 肉、鱼、蛋及豆类 瓜菜类 吃多些 水果类 1型糖尿病：自身免疫系统 2型糖尿病：代谢疾病 吃最多 五谷类