●●● o纤维化期或硬化期(2-3个月) 风湿细胞转变为纤维母细胞 风湿小体纤维化,形成梭形小瘢痕
纤维化期或硬化期（2-3个月） 风湿细胞转变为纤维母细胞 风湿小体纤维化，形成梭形小瘢痕
●° Rheumatic heart disease o acute rheumatic heart disease(RHD) inflammation of the valves, myocardium or pericardium o chronic rheumatic heart disease: diffuse and dense scarring of valves permanent dysfunction o Rheumatic pancarditis o多见于青壮年,17-18岁为高峰
Rheumatic heart disease acute rheumatic heart disease(RHD): inflammation of the valves, myocardium, or pericardium chronic rheumatic heart disease: diffuse and dense scarring of valves permanent dysfunction Rheumatic pancarditis 多见于青壮年，17-18岁为高峰
●° Rheumatic endocarditis Sites: mitral and aortic valves · Fibrinoid necrosis Vegetations: small(1-2mm), warty, along the lines of closure
Rheumatic endocarditis • Sites: mitral and aortic valves • Fibrinoid necrosis • Vegetations: small (1-2mm), warty, along the lines of closure
●●● The small verrucous vegetations seen along the closure line of this mitral valve are associated with acute rheumatic fever These warty vegetations average only a few millimeters and form along the line of valve closure over areas of endocardial inflammation Such verrucae are too small to cause serious cardiac problems