●●● Antigen antibody cross reaction theory immune response Lymph node Antiseep srop good vessel ACUTE RHEUMATIC HEART DISEASE DEPOSITION OF CROSS-REACTIVE ANTIBCDY Myocard al Aschoff body Fiberous pancarditis
Antigen antibody cross reaction theory
●。| Morphology o变质渗出期(1 month) mucoid degeneration and fibrinoid necrosis serous. fibrinous exudate leukocytes infiltration complete resolution fibrosis granulomas
Morphology 变质渗出期(1 month) mucoid degeneration and fibrinoid necrosis serous, fibrinous exudate leukocytes infiltration complete resolution fibrosis granulomas
·|增生期或肉芽肿期(2-3个月) o characterized by Aschoff body(风湿小 体) Aschoff cells(Anitschkow cells Aschoff giant cells fibrinoid necrosis lymphocytes plasma cells
增生期或肉芽肿期（2-3个月） characterized by Aschoff body(风湿小 体) Aschoff cells (Anitschkow cells) Aschoff giant cells fibrinoid necrosis lymphocytes plasma cells
●●● Here is an Aschoff nodule at high magnification. The most characteristic component is the Aschoff giant cell. Several appear here as large cells with two or more nuclei that have prominent nucleoli. Scattered inflammatory cells accompany them and can be mononuclears or occasionally neutrophils
风湿细胞:组织细胞增生聚集,吞噬纤维素样坏死形成 体积大,圆形或多边形,胞质丰富嗜双色 核大、圆或卵圆,核膜清晰,染色质呈细丝状放散 又称枭眼细胞(aw- eye cell),毛虫细胞( caterpillar cell
风湿细胞：组织细胞增生聚集，吞噬纤维素样坏死形成 体积大，圆形或多边形，胞质丰富嗜双色 核大、圆或卵圆，核膜清晰，染色质呈细丝状放散 又称枭眼细胞(awl –eye cell)，毛虫细胞(caterpillar cell)