Section I The Cells and It's Basic Changes of Nervous System I.Neuron The neuron is a pyramidal cell with a rounded nucleus and prominent nucleolus. The granularity of the cytoplasm is imparted by rough endoplasmic reticulum(Nissl substance)
Section I The Cells and It’s Basic Changes of Nervous System I. Neuron The neuron is a pyramidal cell with a rounded nucleus and prominent nucleolus. The granularity of the cytoplasm is imparted by rough endoplasmic reticulum (Nissl substance)
Basic Changes of Neuron: (I)Acute injury Neuron necrosis (red neuron,ghost cell) Neuronophagia (Il )Simple neuronal atrophy e.g.Neuronal transsynaptic degeneration (Ill)Central chromatolysis(Disapearance of central Nissl body )and Waller degeneration (IV)Forming of inclusions e.g.Negri body (V)Abnormalities of the structural proteins e.g.neurofibrillary tangle-Alzheimer disease Lewy body formation-Parkinson disease
Basic Changes of Neuron： ( I ) Acute injury Neuron necrosis (red neuron, ghost cell) Neuronophagia ( II ) Simple neuronal atrophy e.g.Neuronal transsynaptic degeneration (III) Central chromatolysis (Disapearance of central Nissl body ) and Waller degeneration (IV) Forming of inclusions e.g. Negri body (V) Abnormalities of the structural proteins e.g. neurofibrillary tangle — Alzheimer disease Lewy body formation — Parkinson disease
Red Neuron
red neuron Red Neuron
Neuronophagia Phagocytic cells may accumulate at sites of neuronal necrosis,as shown in this case of acute poliomyelitis
Neuronophagia Phagocytic cells may accumulate at sites of neuronal necrosis, as shown in this case of acute poliomyelitis
Central Chromatolysis Normal Neuron The perikaryon(cell body)swells;The nucleus migrates peripherally The Nissl bodies are dispersed to the periphery of the perikaryon
Central Chromatolysis The perikaryon (cell body) swells; The nucleus migrates peripherally The Nissl bodies are dispersed to the periphery of the perikaryon Normal Neuron