Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering

Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering

Lecture 5: Controlled Release Devices Last time: Using enzyme substrate and cytokine peptides to engineer biological recognition of synthetic polymers Today: principles of controlled release devices based on degradable polymers Synthesis of controlled release devices Theory of polymer-based controlled release

Example: HIV-1 DNA vaccine delivered with boosters to elevate Ab titers2: Mechanical and electrical devices that can provide digitized release typically require larger devices and surgical implantation(e.g. Pharm. Res. 1, 237(1984); also have high cost

Molecular Principles of Biomaterials Spring 2003 Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Materials Chemistry of Biodegradable Materials Hydrolytically degraded biomaterials Common hydrolytically unstable linkages Ester

Lecture 3: Degradable Materials with Biological Recognition Last time: Theory of hydrolytic polymer erosion Enzymatic degradation of polymers Designing Biodegradable Macromolecules Today: Biological recognition in vivo Engineering biological recognition of biomaterials: cell adhesion/migration Reading: S.E. Sakiyama-Elbert and J.A. Hubbell, 'Functional Biomaterials: Design of Novel

Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Solid Polymeric Materials(continued) hemistry and physical chemistry of degrading polymeric solids for biomaterials Today Theory of polymer erosion Enzymatic degradation of synthetic biomaterials Designing degradable materials Reading

Biological recognition in vivo Engineering biological recognition of biomaterials: adhesion/migration peptides Engineering biological recognition of biomaterials: enzymatic recognition and cytokine Reading S.E. Sakiyama-Elbert and J.A. Hubbell, Functional Biomaterials: Design of Novel

Biodegradable solid polymeric Materials Today course overview and administrative details Intro to concepts covered Chemistry and physical chemistry of biodegradable polymeric solids Hand-outs course syllabus Course administrative details Readin Third-Generation Biomedical Materials. \LL Hench and j M. Polak. Science 295

燕麦( Avena sativa L.)具有许多农业上重要的性状。但小麦和燕麦分类上属不同族,亲缘 关系较远,有性杂交十分困难。近年来,在双子叶模式植物上建立的只转移供体亲本部分遗传 物质的原生质体不对称融合技术为将燕麦有益性状导入小麦提供了可能。实现体细胞杂种定 向不对称的途径有两种:是利用细胞周期停滞在间期的叶肉细胞原生质体为供体亲本与作 为受体亲本的培养细胞原生质体融合由于二者分裂速度的差异,使前者染色体大量片段化 ( fragmentation)而被消除( Bravo et al.,1985; Dudits et al.,1988);再是利用高于致死剂量的 电离射线处理供体亲本原生质体使其遗传物质大量消除后再与受体融合( Gleba et al 1990)