molecular switches Proteins as motors in nanodevices Today. nano-and micro-particle drug carriers Reading D A Hammer and D.E. Discher, ' Synthetic cells- Self-assembling polymer membranes and bioadhesive colloids, Annu. Rev. Mater Res, 31, 387-404 (2001) Nano- and Micro-scale Drug Carriers and Detection Reagents Nano- to Micro-particle polymer-protein

Lecture 11: Molecular Design and Synthesis of Biomaterials Il: Inorganic Biomaterials Last time: hydrogel applications: molecular imprinting and responsive drug delivery Today biomineralization and biomimetic inorganic/organic composites Inorganic biomaterials Reading L A. Estroff and A D. Hamilton, ' At the interface of organic and inorganic chemistry

Molecular switches in the cell: fibronectin as a mechanical switch (vogel, 2002) Fibronectin is an adhesion protein secreted by cells and assembled into fibrils to support adhesion and migration Composed of\ of fibronectin repeats Fnl, Fnll, and Fnlll connected by short linkers of varying flexibility One particular Fnlll repeat, Fnlll10

Lecture 12: Organic templating of inorganic materials and bone biomimesis Last time interfacial biomineralization and biomimetic inorganic chemistry Today biological strategies for inorganic templating by organic materials Biomimetic

Brannon-Peppas theory of swelling in ionic hydrogels Original theory for elastic networks developed by Flory and Mehrer, refined for treatment of ionic hydrogels by Brannon-Peppas and Peppas Other theoretical treatments Derivation of ionic hydrogel swelling Model structure of the system

Hydrogels in drug delivery Control of drug release kinetics by hydrogel structure6, Release from stable hydrogels is controlled by diffusion of solute through the network Diffusion is described by Fick,s second law

Lecture 8: Physical Hydrogels Last Day Overview of biomedical applications of hydrogels Structure of covalent hydrogels Thermodynamics of hydrogel swelling Today Bonding in physical hydrogels Structure and thermodynamics of block copolymer hydrog Reading

Lecture 9: Polyelectrolyte Hydrogels Last Day: Physical hydrogels Structure and chemistry Toda polyelectrolyte hydrogels, complexes, and coacervates rolyte multilayer theory of swelling in ionic hydrogels Reading S.K. De et aL., 'Equilibrium swelling and kinetics of pH-responsive hydrogels: Models experiments, and simulations

Lecture 10: Bioengineering applications of hydrogels: Molecular Imprinting and Drug Delivery Last Day polyelectrolyte gels Polyelectrolyte complexes and multilayers Applications in bioengineering Theory of ionic gel swelling Toda Molecular imprinting

Lecture 6: Biodegradable Polymers for Tissue Engineering Last time: enzymatic degradation of solid polymers Engineering biological recognition of polymers Toda Designing polymers for tissue engineering Reading